- Primary closure versus delayed or no closure for traumatic wounds due to mammalian bite
Cochrane Systematic Reviews, 6-Dec-2019
Mammalian bites are a common presentation in emergency and primary healthcare facilities across the world. The World Health Organization recommends postponing the suturing of a bite wound but this has not been evaluated through a systematic review. - (1→3)‐β‐D‐glucan testing for the detection of invasive fungal infections in immunocompromised or critically ill people
Cochrane Systematic Reviews, 21-Jul-2020
Invasive fungal infections (IFIs) are life-threatening opportunistic infections that occur in immunocompromised or critically ill people. Early detection and treatment of IFIs is essential to reduce morbidity and mortality in these populations. (1?3)-ß-D- - (Ultra‐)long‐acting insulin analogues for people with type 1 diabetes mellitus
Cochrane Systematic Reviews, 4-Mar-2021
People with type 1 diabetes mellitus (T1DM) need treatment with insulin for survival. Whether any particular type of (ultra-)long-acting insulin provides benefit especially regarding risk of diabetes complications and hypoglycaemia is unknown. - (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus
Cochrane Systematic Reviews, 9-Nov-2020
Evidence that antihyperglycaemic therapy is beneficial for people with type 2 diabetes mellitus is conflicting. While the United Kingdom Prospective Diabetes Study (UKPDS) found tighter glycaemic control to be positive, other studies, such as the Action t - 11C‐PIB‐PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
Cochrane Systematic Reviews, 23-Jul-2014
According to the latest revised National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (now known as the Alzheimer's Association) (NINCDS-ADRDA) diagnostic criteria for Alzhe - 123I‐MIBG scintigraphy and 18F‐FDG‐PET imaging for diagnosing neuroblastoma
Cochrane Systematic Reviews, 29-Sep-2015
Neuroblastoma is an embryonic tumour of childhood that originates in the neural crest. It is the second most common extracranial malignant solid tumour of childhood. - 18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Cochrane Systematic Reviews, 22-Nov-2017
18F-florbetaben uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with deme - 18F PET with florbetapir for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
Cochrane Systematic Reviews, 22-Nov-2017
18F-florbetapir uptake by brain tissue measured by positron emission tomography (PET) is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dement - 18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Cochrane Systematic Reviews, 22-Nov-2017
18F-flutemetamol uptake by brain tissue, measured by positron emission tomography (PET), is accepted by regulatory agencies like the Food and Drug Administration (FDA) and the European Medicine Agencies (EMA) for assessing amyloid load in people with dem - 18F‐FDG PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI)
Cochrane Systematic Reviews, 28-Jan-2015
¹8F-FDFG uptake by brain tissue as measured by positron emission tomography (PET) is a well-established method for assessment of brain function in people with dementia. Certain findings on brain PET scans can potentially predict the decline of mild cognit - 20 µg versus >20 µg estrogen combined oral contraceptives for contraception
Cochrane Systematic Reviews, 1-Aug-2013
Concern about estrogen-related adverse effects has led to progressive reductions in the estrogen dose in combination oral contraceptives (COCs). However, reducing the amount of estrogen to improve safety could result in decreased contraceptive effectivene - 5-alpha-reductase inhibitors for prostate cancer prevention
Cochrane Systematic Reviews, 17-Jan-2012
Five-alpha-reductase inhibitors (5ARI) are frequently used to treat bothersome lower urinary tract symptoms associated with benign prostatic hyperplasia and male androgenic alopecia. They have potential as chemopreventive agents. - 5-Fluorouracil for glaucoma surgery
Cochrane Systematic Reviews, 18-Feb-2014
Trabeculectomy is performed as a treatment for many types of glaucoma in an attempt to lower the intraocular pressure. The surgery involves creating a channel through the sclera, through which intraocular fluid can leave the eye. If scar tissue blocks the - 5‐FU for genital warts in non‐immunocompromised individuals
Cochrane Systematic Reviews, 14-Apr-2010
Genital warts are common and usually are harmless but can be painful and psychologically burdensome. Several local treatments can be used, including topical 5-Fluorouracil (5-FU). - A comparison of different antibiotic regimens for the treatment of infective endocarditis
Cochrane Systematic Reviews, 14-May-2020
Infective endocarditis is a microbial infection of the endocardial surface of the heart. Antibiotics are the cornerstone of treatment, but due to the differences in presentation, populations affected, and the wide variety of micro-organisms that can be re - A realist review of which advocacy interventions work for which abused women under what circumstances
Cochrane Systematic Reviews, 29-Jun-2019
Intimate partner abuse (including coercive control, physical, sexual, economic, emotional and economic abuse) is common worldwide. Advocacy may help women who are in, or have left, an abusive intimate relationship, to stop or reduce repeat victimisation a - A 'test and treat' strategy for elevated wound protease activity for healing in venous leg ulcers
Cochrane Systematic Reviews, 15-Jan-2016
Venous leg ulcers are a common and recurring type of complex wound. They can be painful, malodorous, prone to infection and slow to heal. Standard treatment includes compression therapy and a dressing. The use of protease-modulating treatments for venous - A therapeutic‐only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation
Cochrane Systematic Reviews, 30-Sep-2015
Platelet transfusions are used in modern clinical practice to prevent and treat bleeding in thrombocytopenic patients with bone marrow failure. Although considerable advances have been made in platelet transfusion therapy in the last 40 years, some areas - Ab interno supraciliary microstent surgery for open‐angle glaucoma
Cochrane Systematic Reviews, 28-May-2021
Glaucoma is the leading cause of global irreversible blindness, often associated with raised intraocular pressure (IOP). Where medical or laser treatment has failed or is not tolerated, surgery is often required. Minimally-invasive surgical approaches hav - Ab interno trabecular bypass surgery with iStent for open-angle glaucoma
Cochrane Systematic Reviews, 22-Mar-2019
Glaucoma is a leading cause of irreversible blindness worldwide. In early stages, glaucoma results in progressive loss of peripheral (side) vision; in later stages, it results in loss of central vision leading to blindness. Elevated intraocular pressure (
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