- Dental extractions prior to radiotherapy to the jaws for reducing post‐radiotherapy dental complications
Cochrane Systematic Reviews, 28-Feb-2013
Radiotherapy as part of head and neck cancer treatment leaves patients requiring much dental rehabilitation in a compromised environment that is difficult for the patient and the dental team to manage. - Dental fillings for the treatment of caries in the primary dentition
Cochrane Systematic Reviews, 17-Oct-2016
Childhood caries (tooth decay) consists of a form of tooth decay that affects the milk teeth (also known as baby or primary teeth) of children. This may range from tooth decay in a single tooth to rampant caries affecting all the teeth in the mouth. Prima - Depot fluspirilene for schizophrenia
Cochrane Systematic Reviews, 24-Jan-2007
Antipsychotic drugs are the mainstay treatment for schizophrenia and similar psychotic disorders. Long-acting depot injections of drugs such as fluspirilene are extensively used as a means of long-term maintenance treatment. - Depot haloperidol decanoate for schizophrenia
Cochrane Systematic Reviews, 25-Jan-1999
The mainstay of treatment for schizophrenia is the antipsychotic group of drugs. These are usually given orally but compliance with medication given by this route may be difficult to quantify. Problems with treatment adherence are common. The development - Depot medroxyprogesterone versus Norethisterone oenanthate for long-acting progestogenic contraception.
Cochrane Systematic Reviews, 7-Mar-2012
There are two injectable progestogen-only contraceptives (IPCs) that have been available in many countries in the world since 1983. They are both still extensively used in many developing countries, forming a large proportion of the health system's expend - Depot perphenazine decanoate and enanthate for schizophrenia
Cochrane Systematic Reviews, 20-Jul-2005
Antipsychotic drugs are usually given orally but compliance with medication given by this route may be difficult to quantify. The development of depot injections in the 1960s gave rise to extensive use of depots as a means of long-term maintenance treatme - Depot pipotiazine palmitate and undecylenate for schizophrenia
Cochrane Systematic Reviews, 19-Jul-2004
Antipsychotic drugs are usually given orally but compliance may be problematic. The development of depot injections in the 1960s gave rise to their extensive use as a means of long-term maintenance treatment. Pipotiazine palmitate is a depot from the phen - Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation in assisted reproduction cycles
Cochrane Systematic Reviews, 31-Jan-2013
Gonadotrophin-releasing hormone agonist (GnRHa) is commonly used to switch off (down regulate) the pituitary gland and thus suppress ovarian activity in women undergoing in vitro fertilisation (IVF). Other fertility drugs (gonadotrophins) are then used to - Deprescribing versus continuation of chronic proton pump inhibitor use in adults
Cochrane Systematic Reviews, 16-Mar-2017
Proton pump inhibitors (PPIs) are a class of medications that reduce acid secretion and are used for treating many conditions such as gastroesophageal reflux disease (GERD), dyspepsia, reflux esophagitis, peptic ulcer disease, and hypersecretory condition - Dermoscopy, with and without visual inspection, for diagnosing melanoma in adults
Cochrane Systematic Reviews, 4-Dec-2018
Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a suspicious lesion b - Descemet's membrane endothelial keratoplasty (DMEK) versus Descemet's stripping automated endothelial keratoplasty (DSAEK) for corneal endothelial failure
Cochrane Systematic Reviews, 25-Jun-2018
Corneal endothelial transplantation has become the gold standard for the treatment of corneal endothelial dysfunctions, replacing full thickness transplantation, known as penetrating keratoplasty. Corneal endothelial transplantation has been described usi - Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion‐dependent thalassaemia
Cochrane Systematic Reviews, 21-Aug-2013
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions. - Desipramine for neuropathic pain in adults
Cochrane Systematic Reviews, 23-Sep-2014
Antidepressants are widely used to treat chronic neuropathic pain (pain due to nerve damage), usually in doses below those at which they exert antidepressant effects. An earlier review that included all antidepressants for neuropathic pain is being replac - Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders
Cochrane Systematic Reviews, 13-Feb-2019
Congenital bleeding disorders can cause obstetric haemorrhage during pregnancy, labour and following delivery. Desmopressin acetate (DDAVP) is found to be an effective drug which can reduce the risk of haemorrhage and can also stop bleeding in certain con - Desmopressin for nocturnal enuresis in children
Cochrane Systematic Reviews, 22-Jul-2002
Enuresis (bed-wetting) is a socially disruptive and stressful condition which affects from 15% to 20% of five year olds, and up to 2% of young adults. - Desmopressin for treating nocturia in men
Cochrane Systematic Reviews, 21-Oct-2017
Nocturia is the bothersome symptom of awakening one or more times per night to void. Desmopressin is a commonly used medication for treating nocturia. - Desmopressin use for minimising perioperative blood transfusion
Cochrane Systematic Reviews, 10-Jul-2017
Blood transfusion is administered during many types of surgery, but its efficacy and safety are increasingly questioned. Evaluation of the efficacy of agents, such as desmopressin (DDAVP; 1-deamino-8-D-arginine-vasopressin), that may reduce perioperative - Detoxification treatments for opiate dependent adolescents
Cochrane Systematic Reviews, 29-Apr-2014
The scientific literature examining effective treatments for opioid dependent adults clearly indicates that pharmacotherapy is a necessary and acceptable component of effective treatments for opioid dependence. Nevertheless, no studies have been published - Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia
Cochrane Systematic Reviews, 29-Oct-2018
Intermediate hyperglycaemia (IH) is characterised by one or more measurements of elevated blood glucose concentrations, such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevated glycosylated haemoglobin A1c (HbA1c). These level - Developmental care for promoting development and preventing morbidity in preterm infants
Cochrane Systematic Reviews, 19-Apr-2006
Preterm infants experience a range of morbidity related to the immaturity of their organ systems and to concurrent disease states. There is concern that an unfavourable environment in the neonatal intensive care unit (NICU) may compound this morbidity. Mo
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