- Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer
Cochrane Systematic Reviews, 3-Jan-2019
People with cancer with febrile neutropenia are at risk of severe infections and mortality and are thus treated empirically with broad-spectrum antibiotic therapy. However, the recommended duration of antibiotic therapy differs across guidelines. - Early emergency department treatment of acute asthma with systemic corticosteroids
Cochrane Systematic Reviews, 22-Jan-2001
The airway edema and secretions associated with acute asthma are most effectively treated with anti-inflammatories such as corticosteroids delivered by inhaled, oral, intravenous or intra-muscular routes. There is an unresolved debate about the use of sys - Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults
Cochrane Systematic Reviews, 30-Oct-2019
Early enteral nutrition support (within 48 hours of admission or injury) is frequently recommended for the management of patients in intensive care units (ICU). Early enteral nutrition is recommended in many clinical practice guidelines, although there ap - Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications
Cochrane Systematic Reviews, 22-Jul-2019
This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth', where patients receive fluids followed by solids after bo - Early erythropoiesis‐stimulating agents in preterm or low birth weight infants
Cochrane Systematic Reviews, 11-Feb-2020
Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC - Early fortification of human milk versus late fortification to promote growth in preterm infants
Cochrane Systematic Reviews, 29-Jul-2020
Uncertainty exists about the optimal point at which multi-component fortifier should be added to human milk for promoting growth in preterm infants. The most common practice is to start fortification when the infant’s daily enteral feed volume reaches 100 - Early full enteral feeding for preterm or low birth weight infants
Cochrane Systematic Reviews, 27-Dec-2020
The introduction and advancement of enteral feeds for preterm or low birth weight infants is often delayed because of concerns that early full enteral feeding will not be well tolerated or may increase the risk of necrotising enterocolitis. Early full ent - Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD)
Cochrane Systematic Reviews, 9-May-2018
The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effect - Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit
Cochrane Systematic Reviews, 27-Mar-2018
Survivors of critical illness often experience a multitude of problems that begin in the intensive care unit (ICU) or present and continue after discharge. These can include muscle weakness, cognitive impairments, psychological difficulties, reduced physi - Early intervention for psychosis
Cochrane Systematic Reviews, 10-Mar-2011
Proponents of early intervention have argued that outcomes might be improved if more therapeutic efforts were focused on the early stages of schizophrenia or on people with prodromal symptoms. Early intervention in schizophrenia has two elements that are - Early intravenous nutrition for the prevention of neonatal jaundice
Cochrane Systematic Reviews, 21-Jul-2003
The early institution of enteral feeding in the first few days of life is known to impact on the development of unconjugated hyperbilirubinaemia. However, the effect of early intravenous nutrition on neonatal jaundice remains unknown. - Early introduction of lipids to parenterally-fed preterm infants
Cochrane Systematic Reviews, 29-Oct-2008
Lipids are essential components of parenteral nutrition for preterm infants. Parenteral lipids can be administered through a peripheral vein, and their early introduction offers the potential advantages of increasing energy intake and providing essential - Early light reduction for preventing retinopathy of prematurity in very low birth weight infants
Cochrane Systematic Reviews, 6-Aug-2013
Retinopathy of prematurity (ROP) is a complex condition of the developing retinal blood vessels and is one of the leading causes of preventable childhood blindness. Several risk factors for ROP have been studied over the past 50 years. Among them, general - Early mobilisation for elbow fractures in adults
Cochrane Systematic Reviews, 1-May-2011
A fall on the outstretched arm can result in an elbow fracture. Loss of elbow function is a common problem with these fractures and can have major implications for functional capabilities. It is unknown whether early mobilisation can improve functional ou - Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants
Cochrane Systematic Reviews, 15-Dec-2016
Nasal continuous positive airway pressure (NCPAP) is a strategy for maintaining positive airway pressure throughout the respiratory cycle through the application of bias flow of respiratory gas to an apparatus attached to the nose. Treatment with NCPAP is - Early palliative care for adults with advanced cancer
Cochrane Systematic Reviews, 12-Jun-2017
Incurable cancer, which often constitutes an enormous challenge for patients, their families, and medical professionals, profoundly affects the patient's physical and psychosocial well-being. In standard cancer care, palliative measures generally are init - Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers
Cochrane Systematic Reviews, 6-Jan-2022
Primary malignant brain tumours can have an unpredictable course, but high-grade gliomas typically have a relentlessly progressive disease trajectory. They can cause profound symptom burden, affecting physical, neurocognitive, and social functioning from - Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD)
Cochrane Systematic Reviews, 10-Feb-2022
Post-traumatic stress disorder (PTSD) is a severe and debilitating condition. Several pharmacological interventions have been proposed with the aim to prevent or mitigate it. These interventions should balance efficacy and tolerability, given that not all - Early planned removal of umbilical venous catheters to prevent infection in newborn infants
Cochrane Systematic Reviews, 24-Aug-2017
Lengthy duration of use may be a risk factor for umbilical venous catheter-associated bloodstream infection in newborn infants. Early planned removal of umbilical venous catheters (UVCs) is recommended to reduce the incidence of infection and associated m - Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants
Cochrane Systematic Reviews, 25-Jun-2018
Duration of use may be a modifiable risk factor for central venous catheter-associated bloodstream infection in newborn infants. Early planned removal of peripherally inserted central catheters (PICCs) is recommended as a strategy to reduce the incidence
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