Showing 4041-4060 of 7110 for: Cochrane Systematic Reviews Back
- Methods of repair for obstetric anal sphincter injury
Cochrane Systematic Reviews, 10-Dec-2013
Anal sphincter injury during childbirth - obstetric anal sphincter injuries (OASIS) - are associated with significant maternal morbidity including perineal pain, dyspareunia (painful sexual intercourse) and anal incontinence, which can lead to psychologic
- Methods of term labour induction for women with a previous caesarean section
Cochrane Systematic Reviews, 21-Feb-2013
Induction of labour is a common obstetric intervention, with between 20% and 30% of births reported to occur following induction of labour. Women with a prior caesarean delivery have an increased risk of uterine rupture, particularly when labour is induce
- Methods of vascular occlusion for elective liver resections
Cochrane Systematic Reviews, 13-Nov-2008
Vascular occlusion is used to reduce blood loss during liver resection surgery. Various methods of vascular occlusion have been suggested.
- Methods of vascular occlusion for elective liver resections
Cochrane Systematic Reviews, 20-Oct-2008
Vascular occlusion is used to reduce blood loss during liver resection surgery. There is considerable controversy regarding whether vascular occlusion should be used or not during elective liver resections. The method of vascular occlusion employed is als
- Methods to decrease blood loss and transfusion requirements for liver transplantation
Cochrane Systematic Reviews, 20-Mar-2012
Excessive blood loss and increased blood transfusion requirements may have significant impact on the short-term and long-term outcomes after liver transplantation.
- Methods to decrease blood loss during liver resection: a network meta-analysis
Cochrane Systematic Reviews, 1-Apr-2014
Liver resection is a major surgery with significant mortality and morbidity. Various methods have been attempted to decrease blood loss and morbidity during elective liver resection. These methods include different methods of vascular occlusion, parenchym
- Methotrexate as a steroid sparing agent for asthma in adults
Cochrane Systematic Reviews, 29-Sep-2008
Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chron
- Methotrexate for ankylosing spondylitis
Cochrane Systematic Reviews, 24-Jan-2013
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown cause, characterized by sacroiliitis and spondylitis. Methotrexate (MTX), a widely used disease-modifying antirheumatic drug (DMARD), is effective for rheumatoid arthritis (RA), and
- Methotrexate for high‐grade osteosarcoma in children and young adults
Cochrane Systematic Reviews, 11-May-2011
The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has
- Methotrexate for induction of remission in refractory Crohn's disease
Cochrane Systematic Reviews, 5-Aug-2014
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrex
- Methotrexate for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 3-Oct-2014
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Me
- Methotrexate for maintenance of remission in Crohn's disease
Cochrane Systematic Reviews, 23-Aug-2014
Safe and effective long-term treatments that reduce the need for corticosteroids are needed for Crohn's disease. Although purine antimetabolites are moderately effective for maintenance of remission patients often relapse despite treatment with these agen
- Methotrexate for maintenance of remission in ulcerative colitis
Cochrane Systematic Reviews, 10-Aug-2015
Methotrexate, a folate antagonist, is an immunosuppressant drug that is effective for treating several inflammatory disorders including Crohn's disease. Ulcerative colitis, a related chronic inflammatory bowel disease, can be challenging to treat. T his u
- Methotrexate for multiple sclerosis
Cochrane Systematic Reviews, 5-Sep-2010
Methotrexate is a potent immunosuppressant which in theory could reduce relapse rates and delay disease progression in multiple sclerosis (MS). Subsequently, clinical trials of methotrexate have been conducted in people with MS.
- Methotrexate for primary biliary cirrhosis
Cochrane Systematic Reviews, 12-Apr-2010
Methotrexate has been used to treat patients with primary biliary cirrhosis as it possesses immunosuppressive properties. The previously prepared version of this review from 2005 showed that methotrexate seemed to significantly increase mortality in patie
- Methotrexate for treating juvenile idiopathic arthritis
Cochrane Systematic Reviews, 22-Jun-2008
In both adult rheumatoid arthritis (RA) and juvenile arthritis, the focus has shifted from 'inflammation parameters' to more patient centered disability outcomes. In RA this resulted in the development of the Outcome Measures in Arthritis Clinical Trials
- Methotrexate for treating rheumatoid arthritis
Cochrane Systematic Reviews, 4-Jun-2014
Methotrexate is a folic acid antagonist widely used for the treatment of neoplastic disorders. Methotrexate inhibits the synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins by binding to dihydrofolate reductase. Currently, methot
- Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
Cochrane Systematic Reviews, 12-Apr-2015
Methotrexate (MTX) is among the most effective disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) with less toxicity and better tolerability.
- Methyldopa for primary hypertension
Cochrane Systematic Reviews, 12-Aug-2009
Hypertension is associated with an increased risk of stroke, myocardial infarction and congestive heart failure. Methyldopa is a centrally acting antihypertensive agent, which was commonly used in the 1970's and 80's for blood pressure control. Its use at
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
Cochrane Systematic Reviews, 18-Nov-2015
Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed and treated psychiatric disorders in childhood. Typically, children with ADHD find it difficult to pay attention, they are hyperactive and impulsive.
