Showing 421-440 of 723 for: Cochrane Systematic Reviews > Musculoskeletal 
- Methadone for cancer pain
Cochrane Systematic Reviews, 8-Feb-2017
This is an updated review originally published in 2004 and first updated in 2007. This version includes substantial changes to bring it in line with current methodological requirements. Methadone is a synthetic opioid that presents some challenges in dose
- Methotrexate as a steroid sparing agent for asthma in adults
Cochrane Systematic Reviews, 27-Jul-1998
Sustained oral corticosteroid use can lead to complications, so there is interest in identifying agents that can reduce oral steroid use in people with asthma. Methotrexate has attracted attention as a possible steroid sparing agent in patients with chron
- Methotrexate for ankylosing spondylitis
Cochrane Systematic Reviews, 28-Feb-2013
Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown cause, characterized by sacroiliitis and spondylitis. Methotrexate (MTX), a widely used disease-modifying antirheumatic drug (DMARD), is effective for rheumatoid arthritis (RA), and
- Methotrexate for induction of remission in refractory Crohn's disease
Cochrane Systematic Reviews, 6-Aug-2014
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrex
- Methotrexate for treating juvenile idiopathic arthritis
Cochrane Systematic Reviews, 23-Oct-2001
In both adult rheumatoid arthritis (RA) and juvenile arthritis, the focus has shifted from 'inflammation parameters' to more patient centered disability outcomes. In RA this resulted in the development of the Outcome Measures in Arthritis Clinical Trials
- Methotrexate for treating rheumatoid arthritis
Cochrane Systematic Reviews, 10-Jun-2014
Methotrexate is a folic acid antagonist widely used for the treatment of neoplastic disorders. Methotrexate inhibits the synthesis of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins by binding to dihydrofolate reductase. Currently, methot
- Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis
Cochrane Systematic Reviews, 12-Apr-2015
Methotrexate (MTX) is among the most effective disease modifying anti-rheumatic drugs (DMARDs) in rheumatoid arthritis (RA) with less toxicity and better tolerability.
- Milnacipran for pain in fibromyalgia in adults
Cochrane Systematic Reviews, 22-May-2019
This is an updated version of the original Cochrane review published in Issue 3, 2012. That review considered both fibromyalgia and neuropathic pain, but the efficacy of milnacipran for neuropathic pain is now dealt with in a separate review.
- Mirror therapy for improving motor function after stroke
Cochrane Systematic Reviews, 11-Jul-2018
Mirror therapy is used to improve motor function after stroke. During mirror therapy, a mirror is placed in the person's midsagittal plane, thus reflecting movements of the non-paretic side as if it were the affected side.
- Mobile bearing vs fixed bearing prostheses for posterior cruciate retaining total knee arthroplasty for postoperative functional status in patients with osteoarthritis and rheumatoid arthritis
Cochrane Systematic Reviews, 4-Feb-2015
It is unclear whether there are differences in benefits and harms between mobile and fixed prostheses for total knee arthroplasty (TKA). The previous Cochrane review published in 2004 included two articles. Many more trials have been performed since then;
- Moderately early (7‐14 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants
Cochrane Systematic Reviews, 20-Jan-2003
Corticosteroids have been used late in the neonatal period to treat chronic lung disease (CLD) in preterm babies, and early to try to prevent it. CLD is likely to be the result of persisting inflammation in the lung and the use of powerful anti-inflammato
- Moderate‐term, low‐dose corticosteroids for rheumatoid arthritis
Cochrane Systematic Reviews, 27-Jul-1998
Low dose corticosteroid use in RA is currently widespread with up to 80% of patients using prednisone or similar corticosteroid preparations in many arthritis practices, but the value of corticosteroids for the treatment of RA has been debated by several
- Modification of the home environment for the reduction of injuries
Cochrane Systematic Reviews, 16-Feb-2011
Injury in the home is common, accounting for approximately a third of all injuries. The majority of injuries to children under five and people aged 75 and older occur at home. Multifactorial injury prevention interventions have been shown to reduce injuri
- Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome
Cochrane Systematic Reviews, 8-Mar-2012
Fibromyalgia (FM) syndrome is a chronic condition of unknown aetiology characterised by musculoskeletal pain that often co-exists with sleep disturbance, cognitive dysfunction and fatigue. Patients often report high disability levels and poor quality of l
- Multidisciplinary biopsychosocial rehabilitation for chronic low back pain
Cochrane Systematic Reviews, 29-Aug-2014
Low back pain (LBP) is responsible for considerable personal suffering worldwide. Those with persistent disabling symptoms also contribute to substantial costs to society via healthcare expenditure and reduced work productivity. While there are many treat
- Multidisciplinary biopsychosocial rehabilitation for neck and shoulder pain among working age adults
Cochrane Systematic Reviews, 22-Apr-2003
Multidisciplinary biopsychosocial rehabilitation programs for neck and shoulder pain require substantial staff and financial resources. Despite questionable scientific evidence of their effectiveness, they are widely used.
- Multidisciplinary biopsychosocial rehabilitation for subacute low back pain
Cochrane Systematic Reviews, 28-Jun-2017
Low back pain (LBP) is associated with enormous personal and societal burdens, especially when it reaches the chronic stage of the disorder (pain for a duration of more than three months). Indeed, individuals who reach the chronic stage tend to show a mor
- Multidisciplinary care for Guillain-Barré syndrome
Cochrane Systematic Reviews, 7-Sep-2010
Guillain-Barré syndrome is a significant cause of new long-term disability, which is thought to be amenable to multidisciplinary care, but the evidence base for its effectiveness is unclear.
- Multi‐disciplinary rehabilitation for acquired brain injury in adults of working age
Cochrane Systematic Reviews, 22-Dec-2015
Evidence from systematic reviews demonstrates that multi-disciplinary rehabilitation is effective in the stroke population, in which older adults predominate. However, the evidence base for the effectiveness of rehabilitation following acquired brain inju
- Multidisciplinary rehabilitation for adults with multiple sclerosis
Cochrane Systematic Reviews, 8-Nov-2011
Multidisciplinary (MD) rehabilitation is an important component of symptomatic and supportive treatment for Multiple Sclerosis (MS), but evidence base for its effectiveness is yet to be established.
