- Metered dose inhalers versus nebulizers for aerosol bronchodilator delivery for adult patients receiving mechanical ventilation in critical care units
Cochrane Systematic Reviews, 21-Dec-2018
Nebulizers and metered dose inhalers (MDI) have both been adapted for delivering aerosol bronchodilation to mechanically ventilated patients, but there is incomplete knowledge as to the most effective method of delivery. - Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents
Cochrane Systematic Reviews, 21-Jan-2009
In adolescents with type 1 diabetes, insulin resistance likely plays a role in the deterioration of metabolic control. In type 1 diabetes, addition of metformin to insulin therapy, to improve insulin sensitivity, has been assessed in a few trials involvin - Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus
Cochrane Systematic Reviews, 18-Apr-2019
The number of people with type 2 diabetes mellitus (T2DM) is increasing worldwide. The combination of metformin and sulphonylurea (M+S) is a widely used treatment. Whether M+S shows better or worse effects in comparison with other antidiabetic medications - Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome
Cochrane Systematic Reviews, 24-Jan-2017
Clomiphene citrate (CC) is generally considered first-line treatment in women with anovulation due to polycystic ovary syndrome (PCOS). Ovulation induction with follicle-stimulating hormone (FSH; gonadotrophins) is second-line treatment for women who do n - Metformin for endometrial hyperplasia
Cochrane Systematic Reviews, 26-Oct-2017
Endometrial cancer is one of the most common gynaecological cancers in the world. Rates of endometrial cancer are rising, in part because of rising obesity rates. Endometrial hyperplasia is a precancerous condition in women that can lead to endometrial ca - Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome
Cochrane Systematic Reviews, 17-Dec-2019
Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with an increased biochemical ris - Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus
Cochrane Systematic Reviews, 3-Dec-2019
The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether metformin can prevent or delay T2DM and its complications in people with increased risk of developing T2DM is unknown - Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
Cochrane Systematic Reviews, 24-Jul-2018
There has been considerable interest in providing antenatal dietary and lifestyle advice for women with obesity or who are overweight during pregnancy, as a strategy to limit gestational weight gain and improve maternal and infant health. However, such an - Metformin monotherapy for adults with type 2 diabetes mellitus
Cochrane Systematic Reviews, 5-Jun-2020
Worldwide, there is an increasing incidence of type 2 diabetes mellitus (T2DM). Metformin is still the recommended first-line glucose-lowering drug for people with T2DM. Despite this, the effects of metformin on patient-important outcomes are still not cl - Metformin monotherapy for type 2 diabetes mellitus
Cochrane Systematic Reviews, 30-Sep-2015
Metformin is an anti-hyperglycaemic agent used for the treatment of type 2 diabetes mellitus. Type 2 diabetes may present long-term complications: micro- (retinopathy, nephropathy and neuropathy) and macrovascular (stroke, myocardial infarction and periph - Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome
Cochrane Systematic Reviews, 16-Apr-2015
The use of insulin-sensitising agents, such as metformin, in women with polycystic ovary syndrome (PCOS) who are undergoing ovulation induction or in vitro fertilisation (IVF) cycles has been widely studied. Metformin reduces hyperinsulinaemia and suppres - Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome
Cochrane Systematic Reviews, 13-Aug-2020
Metformin has been proposed as possibly a safer and more effective long-term treatment than the oral contraceptive pill (OCP) in women with polycystic ovary syndrome (PCOS). It is important to directly compare the efficacy and safety of metformin versus O - Methadone at tapered doses for the management of opioid withdrawal
Cochrane Systematic Reviews, 28-Feb-2013
The evidence of tapered methadone's efficacy in managing opioid withdrawal has been systematically evaluated in the previous version of this review that needs to be updated - Methadone for cancer pain
Cochrane Systematic Reviews, 8-Feb-2017
This is an updated review originally published in 2004 and first updated in 2007. This version includes substantial changes to bring it in line with current methodological requirements. Methadone is a synthetic opioid that presents some challenges in dose - Methadone for chronic non‐cancer pain in adults
Cochrane Systematic Reviews, 14-Nov-2012
Methadone belongs to a class of analgesics known as opioids, that are considered the cornerstone of therapy for moderate-to-severe pain due to life-threatening illnesses; however, their use in chronic non-cancer pain (CNCP) is controversial. Methadone has - Methadone for neuropathic pain in adults
Cochrane Systematic Reviews, 17-May-2017
This review replaces an earlier review, "Methadone for chronic non-cancer pain in adults". This review serves to update the original and includes only studies of neuropathic pain. Methadone belongs to a class of analgesics known as opioids, that are consi - Methadone maintenance at different dosages for opioid dependence
Cochrane Systematic Reviews, 25-Mar-2008
Methadone maintenance treatment (MMT) is a long term opiod replacement therapy, effective in the management of opiod dependence. Even if MMT at high dosage is recommended for reducing illicit opioid use and promoting longer retention in treatment, at pres - Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence
Cochrane Systematic Reviews, 8-Jul-2009
Methadone maintenance was the first widely used opioid replacement therapy to treat heroin dependence, and it remains the best-researched treatment for this problem. Despite the widespread use of methadone in maintenance treatment for opioid dependence in - Methenamine hippurate for preventing urinary tract infections
Cochrane Systematic Reviews, 17-Oct-2012
Methenamine salts are often used as an alternative to antibiotics for the prevention of urinary tract infection (UTI). This review was first published in Issue 1, 2002 and updated in Issue 4, 2007. - Methods for administering subcutaneous heparin during pregnancy
Cochrane Systematic Reviews, 22-Feb-2013
Pregnant women with a history of venous thromboembolism (VTE), antithrombin deficiency, or other risk factors for VTE, need heparin (unfractionated heparin (UFH) or low-molecular weight heparin (LMWH)) prophylaxis, mainly through administering subcutaneou
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