- New generation antidepressants for depression in children and adolescents: a network meta‐analysis
Cochrane Systematic Reviews, 24-May-2021
Major depressive disorders have a significant impact on children and adolescents, including on educational and vocational outcomes, interpersonal relationships, and physical and mental health and well-being. There is an association between major depressiv - New generation antipsychotics for first episode schizophrenia
Cochrane Systematic Reviews, 17-Oct-2012
The new generation antipsychotics are associated with a lower risk of adverse effects compared with drugs such as haloperidol. Many treatment guidelines recommend the use of new generation ('atypical') antipsychotic drugs for people with a first episode o - Newborn screening for cystic fibrosis
Cochrane Systematic Reviews, 21-Jan-2009
Does newborn screening for cystic fibrosis (CF) improve clinical outcomes, quality of life and survival? - Newborn screening for galactosaemia
Cochrane Systematic Reviews, 22-Jun-2020
Classical galactosaemia is an autosomal recessive inborn error of metabolism caused by a deficiency of the enzyme galactose-1-phosphate uridyltransferase. This is a rare and potentially lethal condition that classically presents in the first week of life - Newborn screening for homocystinuria
Cochrane Systematic Reviews, 1-Oct-2015
Homocystinuria is a rare inherited disorder due to a deficiency in cystathionine beta synthase. Individuals with this condition appear normal at birth but develop serious complications in childhood. Diagnosis and treatment started sufficiently early in li - Newer atypical antipsychotic medication versus clozapine for schizophrenia
Cochrane Systematic Reviews, 18-Jan-2012
Clozapine is an atypical antipsychotic drug, which is claimed to have superior efficacy and to cause fewer movement disorders. However, clozapine carries a significant risk of serious blood disorders. Newer atypical antipsychotics are safer alternatives t - Newer generation antidepressants for depressive disorders in children and adolescents
Cochrane Systematic Reviews, 14-Nov-2012
Depressive disorders are common in young people and are associated with significant negative impacts. Newer generation antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), are often used, however evidence of their effectiveness i - Niacin for primary and secondary prevention of cardiovascular events
Cochrane Systematic Reviews, 14-Jun-2017
Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. - Nicergoline for dementia and other age associated forms of cognitive impairment
Cochrane Systematic Reviews, 23-Oct-2001
Nicergoline is an ergot derivative currently in use in over fifty countries for more than three decades, for the treatment of cognitive, affective, and behavioral disorders of older people. It was initially considered as a vasoactive drug and mainly presc - Nicobrevin for smoking cessation
Cochrane Systematic Reviews, 19-Apr-2006
Nicobrevin is a proprietary product marketed as an aid to smoking cessation. It contains quinine, menthyl valerate, camphor and eucalyptus oil. - Nicotine for Alzheimer's disease
Cochrane Systematic Reviews, 9-Jun-2010
Nicotine is a cholinergic agonist that also has a presynaptic effect in releasing acetylcholine. It has been shown to reverse spatial memory deficits produced in rats by lesions in the medial septal nucleus of their brains, and, in aged monkeys, nicotine - Nicotine for schizophrenia
Cochrane Systematic Reviews, 18-Jan-2012
The proportion of people with schizophrenia who smoke is very high, and as a rule, they tend to be heavier smokers when compared to the general population and those with other psychiatric disorders. Nicotine, the psychoactive component in tobacco, is thou - Nicotine receptor partial agonists for smoking cessation
Cochrane Systematic Reviews, 9-May-2016
Nicotine receptor partial agonists may help people to stop smoking by a combination of maintaining moderate levels of dopamine to counteract withdrawal symptoms (acting as an agonist) and reducing smoking satisfaction (acting as an antagonist). - Nicotine replacement therapy versus control for smoking cessation
Cochrane Systematic Reviews, 31-May-2018
Nicotine replacement therapy (NRT) aims to temporarily replace much of the nicotine from cigarettes to reduce motivation to smoke and nicotine withdrawal symptoms, thus easing the transition from cigarette smoking to complete abstinence. - Nicotine vaccines for smoking cessation
Cochrane Systematic Reviews, 14-Nov-2012
By reducing the amount of nicotine that reaches the brain when a person smokes a cigarette, nicotine vaccines may help people to stop smoking or to prevent recent quitters from relapsing. - Nidotherapy for people with schizophrenia
Cochrane Systematic Reviews, 17-Apr-2013
Nidotherapy is a therapeutic method that principally aims to modify the environment of people with schizophrenia and other serious mental illnesses, whilst working in conjunction with, or alongside other treatments. Rather than focusing on direct treatmen - Nifedipine for primary dysmenorrhoea
Cochrane Systematic Reviews, 18-Dec-2021
Dysmenorrhoea (period pain) is a common condition with a substantial impact on the well-being and productivity of women. Primary dysmenorrhoea is defined as recurrent, cramping pelvic pain that occurs with periods, in the presence of a normal uterus, ovar - Nimodipine for primary degenerative, mixed and vascular dementia
Cochrane Systematic Reviews, 22-Jul-2002
Dementia is an age-associated syndrome most commonly due to Alzheimer's disease (AD) and/or cerebrovascular disease. - Nipple- and areola-sparing mastectomy for the treatment of breast cancer
Cochrane Systematic Reviews, 28-Nov-2016
The efficacy and safety of nipple-sparing mastectomy and areola-sparing mastectomy for the treatment of breast cancer are still questionable. It is estimated that the local recurrence rates following nipple-sparing mastectomy are very similar to breast-co - Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19
Cochrane Systematic Reviews, 20-Sep-2022
Oral nirmatrelvir/ritonavir (Paxlovid®) aims to avoid severe COVID-19 in asymptomatic people or those with mild symptoms, thereby decreasing hospitalization and death. Due to its novelty, there are currently few published study results. It remains to be e
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