Showing 561-580 of 746 for: Cochrane Systematic Reviews > Pharmacotherapeutics 
- Plasma exchange for Guillain‐Barré syndrome
Cochrane Systematic Reviews, 27-Feb-2017
Guillain-Barré syndrome (GBS) is an acute paralysing disease caused by peripheral nerve inflammation. This is an update of a review first published in 2001 and last updated in 2012.
- Platelet glycoprotein IIb/IIIa blockers during percutaneous coronary intervention and as the initial medical treatment of non-ST segment elevation acute coronary syndromes
Cochrane Systematic Reviews, 7-Nov-2013
During percutaneous coronary intervention (PCI), and in non-ST segment elevation acute coronary syndromes (NSTEACS), the risk of acute vessel occlusion by thrombosis is high. Glycoprotein IIb/IIIa blockers strongly inhibit platelet aggregation and may pre
- Polyunsaturated fatty acid supplementation for schizophrenia
Cochrane Systematic Reviews, 19-Jul-2006
Limited evidence supports a hypothesis suggesting that the symptoms of schizophrenia may be the result of altered neuronal membrane structure and metabolism. The structure and metabolism is dependent on blood plasma levels of certain essential fatty acids
- Potassium containing toothpastes for dentine hypersensitivity
Cochrane Systematic Reviews, 19-Jul-2006
Dentine hypersensitivity may be defined as the pain arising from exposed dentine, typically in response to external stimuli, and which cannot be explained by any other form of dental disease. Many treatment regimens have been recommended over the years, a
- Pre-emptive treatment for cytomegalovirus viraemia to prevent cytomegalovirus disease in solid organ transplant recipients
Cochrane Systematic Reviews, 29-Jan-2013
Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ transplant recipients. Pre-emptive treatment of patients with CMV viraemia using antiviral agents has been suggested as an alternative to routine prophylaxis to prevent
- Pregabalin add‐on for drug‐resistant focal epilepsy
Cochrane Systematic Reviews, 9-Jul-2019
Epilepsy is a common neurological disease that affects approximately 1% of the UK population. Approximately one-third of these people continue to have seizures despite drug treatment. Pregabalin is one of the newer antiepileptic drugs which have been deve
- Pregabalin for neuropathic pain in adults
Cochrane Systematic Reviews, 23-Jan-2019
This review updates part of an earlier Cochrane Review titled "Pregabalin for acute and chronic pain in adults", and considers only neuropathic pain (pain from damage to nervous tissue). Antiepileptic drugs have long been used in pain management. Pregabal
- Preoperative chemotherapy for resectable thoracic esophageal cancer
Cochrane Systematic Reviews, 19-May-2015
Surgery has been the treatment of choice for patients with localized esophageal cancer. Several studies have investigated whether preoperative chemotherapy followed by surgery leads to improvement in cure rates, but individual reports have provided confli
- Preoperative fasting for adults to prevent perioperative complications
Cochrane Systematic Reviews, 20-Oct-2003
Fasting before general anaesthesia aims to reduce the volume and acidity of stomach contents during surgery, thus reducing the risk of regurgitation/aspiration. Recent guidelines have recommended a shift in fasting policy from the standard 'nil by mouth f
- Pressurised metered dose inhalers versus all other hand‐held inhaler devices to deliver beta‐2 agonist bronchodilators for non‐acute asthma
Cochrane Systematic Reviews, 22-Apr-2002
A number of different inhaler devices are available to deliver beta2-agonist bronchodilators in asthma. These include hydrofluoroalkane (HFA) or chlorofluorocarbon (CFC)-free propelled pressurised metered dose inhalers (pMDIs) and dry powder devices.
- Prevention of NSAID‐induced gastroduodenal ulcers
Cochrane Systematic Reviews, 21-Oct-2002
Non-steroidal anti-inflammatory drugs (NSAIDs) are important agents in the management of arthritic and inflammatory conditions, and are among the most frequently prescribed medications in North America and Europe. However, there is overwhelming evidence l
- Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people
Cochrane Systematic Reviews, 29-Aug-2018
Cryptococcal disease remains one of the main causes of death in HIV-positive people who have low cluster of differentiation 4 (CD4) cell counts. Currently, the World Health Organization (WHO) recommends screening HIV-positive people with low CD4 counts fo
- Probiotics for induction of remission in ulcerative colitis
Cochrane Systematic Reviews, 4-Mar-2020
Ulcerative colitis is an inflammatory condition affecting the colon, with an annual incidence of approximately 10 to 20 per 100,000 people. The majority of people with ulcerative colitis can be put into remission, leaving a group who do not respond to fir
- Probiotics for maintenance of remission in Crohn's disease
Cochrane Systematic Reviews, 16-Jun-2008
Crohn's disease (CD) is characterised by episodes of disease activity and symptom-free remission. Probiotics are microorganisms that can potentially benefit health, and have been evaluated as an alternate means of preventing relapse in patients with CD.
- Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis
Cochrane Systematic Reviews, 9-Nov-2008
Non-alcoholic fatty liver disease comprises a spectrum of diseases ranging from simple steatosis to non-alcoholic steatohepatitis, fibrosis, and cirrhosis. Probiotics have been proposed as a treatment option because of their modulating effect on the gut f
- Probiotics for preventing preterm labour
Cochrane Systematic Reviews, 13-Dec-2011
Preterm birth causes 60% to 80% of neonatal deaths. Survivors can experience life-long complications. Thirty to fifty per cent of preterm labours are associated with maternal infection. Probiotics are defined as live micro-organisms which, when administer
- Probiotics for the prevention of pediatric antibiotic‐associated diarrhea
Cochrane Systematic Reviews, 30-Apr-2019
Antibiotics alter the microbial balance commonly resulting in antibiotic-associated diarrhea (AAD). Probiotics may prevent AAD via providing gut barrier, restoration of the gut microflora, and other potential mechanisms of action.
- Probiotics for treating acute infectious diarrhoea
Cochrane Systematic Reviews, 8-Dec-2020
Probiotics may be effective in reducing the duration of acute infectious diarrhoea.
- Probiotics for treatment of Clostridium difficile-associated colitis in adults
Cochrane Systematic Reviews, 5-May-2008
Probiotics are live microorganisms consisting of non-pathogenic yeast and bacteria that are believed to restore the microbial balance of the gastrointestinal tract altered by infection with Clostridium difficile (C. difficile).
- Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Cochrane Systematic Reviews, 15-Oct-2020
Intestinal dysbiosis may contribute to the pathogenesis of necrotising enterocolitis (NEC) in very preterm or very low birth weight infants. Dietary supplementation with probiotics to modulate the intestinal microbiome has been proposed as a strategy to r
