- Oxytocin receptor antagonists for inhibiting preterm labour
Cochrane Systematic Reviews, 6-Jun-2014
Preterm birth, defined as birth between 20 and 36 completed weeks, is a major contributor to perinatal morbidity and mortality globally. Oxytocin receptor antagonists (ORA), such as atosiban, have been specially developed for the treatment of preterm labo - Oxytocin versus no treatment or delayed treatment for slow progress in the first stage of spontaneous labour
Cochrane Systematic Reviews, 23-Jun-2013
Slow progress in the first stage of spontaneous labour is associated with an increased caesarean section rate and fetal and maternal morbidity. Oxytocin has long been advocated as a treatment for slow progress in labour but it is unclear to what extent it - Ozone therapy for the treatment of dental caries
Cochrane Systematic Reviews, 7-Feb-2019
Dental caries is a bacterially mediated disease characterised by demineralisation of the tooth surface, which may lead to cavitation, discomfort, pain and eventual tooth loss. Ozone is toxic to certain bacteria in vitro and it has been suggested that deli - Ozone therapy for treating foot ulcers in people with diabetes
Cochrane Systematic Reviews, 27-Oct-2015
It has been reported that ozone therapy might be helpful in treating foot ulcers in people with diabetes mellitus (DM). - Pacing for drug‐refractory or drug‐intolerant hypertrophic cardiomyopathy
Cochrane Systematic Reviews, 16-May-2012
Hypertrophic cardiomyopathy (HCM) is a genetic disease with an autosomal-dominant inheritance for which negative inotropes are the most widely used initial therapies. Observational studies and small randomised trials have suggested symptomatic and functio - Package of care for active management in labour for reducing caesarean section rates in low‐risk women
Cochrane Systematic Reviews, 16-Sep-2013
Approximately 15% of women have caesarean sections (CS) and while the rate varies, the number is increasing in many countries. This is of concern because higher CS rates do not confer additional health gain but may adversely affect maternal health and hav - Padma 28 for intermittent claudication
Cochrane Systematic Reviews, 29-Mar-2016
Intermittent claudication (IC) is pain caused by chronic occlusive arterial disease that develops in a limb during exercise and is relieved with rest. Most drug treatments of IC have a limited effect in improving walking distance. Padma 28, a Tibetan herb - Paediatric formulations of artemisinin‐based combination therapies for treating uncomplicated malaria in children
Cochrane Systematic Reviews, 8-Dec-2020
In endemic malarial areas, young children have high levels of malaria morbidity and mortality. The World Health Organization recommends oral artemisinin-based combination therapy (ACT) for treating uncomplicated malaria. Paediatric formulations of ACT hav - Pain control in first trimester surgical abortion
Cochrane Systematic Reviews, 15-Apr-2009
First trimester abortions especially cervical dilation and suction aspiration are associated with pain, despite various methods of pain control. - Pain management for inflammatory arthritis (rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and other spondyloarthritis) and gastrointestinal or liver comorbidity
Cochrane Systematic Reviews, 18-Jan-2012
Even with optimal disease-modifying treatment and good control of disease activity, persistent pain due to structural damage is common in people with inflammatory arthritis and therefore additional treatment for pain might be required. Because comorbidity - Pain management for medical abortion before 14 weeks’ gestation
Cochrane Systematic Reviews, 13-May-2022
Abortion is common worldwide and increasingly abortions are performed at less than 14 weeks’ gestation using medical methods, specifically using a combination of mifepristone and misoprostol. Medical abortion is known to be a painful process, but the opti - Pain management for rheumatoid arthritis and cardiovascular or renal comorbidity
Cochrane Systematic Reviews, 5-Sep-2011
Pain in rheumatoid arthritis is common, is often multi-factorial and many different pharmacotherapeutic agents are routinely used for pain management. There are concerns that some of the pain pharmacotherapies currently used may increase the risk of adver - Pain management for sickle cell disease in children and adults
Cochrane Systematic Reviews, 10-Jun-2019
Sickle cell disease is an inherited genetic disorder characterized by an abnormality of haemoglobin that predisposes to polymerization and consequent deformation ("sickling"). Sickle cell disease can cause episodes of acute severe pain. Chronic pain may a - Pain management for tubal sterilization by hysteroscopy
Cochrane Systematic Reviews, 10-Jul-2012
Tubal sterilization by hysteroscopy involves inserting a foreign body in both fallopian tubes. Over a three-month period, the tubal lumen is occluded by tissue growth stimulated by the insert. Tubal sterilization by hysteroscopy has advantages over laparo - Pain management for women in labour: an overview of systematic reviews
Cochrane Systematic Reviews, 14-Mar-2012
The pain that women experience during labour is affected by multiple physiological and psychosocial factors and its intensity can vary greatly. Most women in labour require pain relief. Pain management strategies include non-pharmacological interventions - Pain relief for neonatal circumcision
Cochrane Systematic Reviews, 19-Jul-2004
Circumcision is a painful procedure that many newborn males undergo in the first few days after birth. Interventions are available to reduce pain at circumcision; however, many newborns are circumcised without pain management. - Pain relief for outpatient hysteroscopy
Cochrane Systematic Reviews, 2-Oct-2010
Hysteroscopy is increasingly performed in an outpatient setting. The primary reason for failure is pain. There is no consensus upon the routine use of analgesia during hysteroscopy. - Pain relief for the removal of femoral sheath after percutaneous coronary intervention
Cochrane Systematic Reviews, 8-Oct-2008
This is an updated version of the original Cochrane Review published in Issue 4, 2008 of The Cochrane Library. There is variation in the use of pain relief for managing pain or discomfort of femoral sheath removal. The efficacy of pain relief to promote c - Pain relief for women undergoing oocyte retrieval for assisted reproduction
Cochrane Systematic Reviews, 15-May-2018
Various methods of conscious sedation and analgesia (CSA) have been used during oocyte retrieval for assisted reproduction. The choice of agent has been influenced by the quality of sedation and analgesia and by concerns about possible detrimental effects - Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment
Cochrane Systematic Reviews, 18-Jul-2016
Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the National Health Service (NHS) cervical screening guidelines suggest that over 80% of treatments should be
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