Showing 41-60 of 197 for: Cochrane Systematic Reviews > Hematologic 
- Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV
Cochrane Systematic Reviews, 21-Jul-2003
The prevention and early treatment of infections are the mainstay of the medical management of the majority of people with HIV infection, who live in low income countries without access to antiretroviral drugs. Cotrimoxazole is cheap and effective against
- Cotrimoxazole prophylaxis for opportunistic infections in children with HIV infection
Cochrane Systematic Reviews, 25-Jan-2006
The majority of children with HIV infection live in low-income countries without access to antiretroviral drugs. The prevention and early treatment of opportunistic infections are the mainstay of their medical management. Cotrimoxazole is cheap and effect
- Daily oral iron supplementation during pregnancy
Cochrane Systematic Reviews, 22-Jul-2015
Iron and folic acid supplementation has been the preferred intervention to improve iron stores and prevent anaemia among pregnant women, and it is thought to improve other maternal and birth outcomes.
- De-escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock
Cochrane Systematic Reviews, 20-Dec-2018
Mortality rates among patients with sepsis, severe sepsis or septic shock are highly variable throughout different regions or services and can be upwards of 50%. Empirical broad-spectrum antimicrobial treatment is aimed at achieving adequate antimicrobial
- Deferasirox for managing iron overload in people with myelodysplastic syndrome
Cochrane Systematic Reviews, 28-Oct-2014
The myelodysplastic syndrome (MDS) comprises a diverse group of haematopoietic stem cell disorders. Due to symptomatic anaemia, most people with MDS require supportive therapy including repeated red blood cell (RBC) transfusions. In combination with incre
- Deferasirox for managing iron overload in people with thalassaemia
Cochrane Systematic Reviews, 15-Aug-2017
Thalassaemia is a hereditary anaemia due to ineffective erythropoiesis. In particular, people with thalassaemia major develop secondary iron overload resulting from regular red blood cell transfusions. Iron chelation therapy is needed to prevent long-term
- Deferasirox for managing transfusional iron overload in people with sickle cell disease
Cochrane Systematic Reviews, 4-Jun-2014
Sickle cell disease (SCD) is a group of genetic haemoglobin disorders, that occurs in about 2.2 per 1000 births worldwide. Increasingly, some people with SCD develop secondary iron overload due to occasional red blood cell transfusions or are on long-term
- Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion‐dependent thalassaemia
Cochrane Systematic Reviews, 21-Aug-2013
Thalassaemia major is a genetic disease characterised by a reduced ability to produce haemoglobin. Management of the resulting anaemia is through red blood cell transfusions.
- Desmopressin use for minimising perioperative blood transfusion
Cochrane Systematic Reviews, 10-Jul-2017
Blood transfusion is administered during many types of surgery, but its efficacy and safety are increasingly questioned. Evaluation of the efficacy of agents, such as desmopressin (DDAVP; 1-deamino-8-D-arginine-vasopressin), that may reduce perioperative
- Disclosing to parents newborn carrier status identified by routine blood spot screening
Cochrane Systematic Reviews, 25-Nov-2013
Newborn blood spot screening programmes are designed to detect serious conditions affecting individuals, where early treatment can improve health. It is suggested that screening can improve the experience of diagnosis for parents. For example, without new
- Drugs for preventing red blood cell dehydration in people with sickle cell disease
Cochrane Systematic Reviews, 19-Oct-2018
Sickle cell disease is an inherited disorder of hemoglobin, resulting in abnormal red blood cells. These are rigid and may block blood vessels leading to acute painful crises and other complications. Recent research has focused on therapies to rehydrate t
- Early versus late pre‐intensive care unit admission broad spectrum antibiotics for severe sepsis in adults
Cochrane Systematic Reviews, 6-Oct-2010
Severe sepsis and septic shock have recently emerged as particularly acute and lethal challenges amongst critically ill patients presenting to the emergency department (ED). There are no existing data on the current practices of management of patients wit
- Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes
Cochrane Systematic Reviews, 17-Sep-2019
Infants born preterm (before 37 weeks' gestation) have poorer outcomes than infants at term, particularly if born before 32 weeks. Early cord clamping has been standard practice over many years, and enables quick transfer of the infant to neonatal care. D
- Efficacy and safety of cesarean delivery for prevention of mother‐to‐child transmission of HIV‐1
Cochrane Systematic Reviews, 19-Oct-2005
Cesarean section before labor and before ruptured membranes ("elective cesarean section", or ECS) has been introduced as an intervention for the prevention of mother-to-child transmission (MTCT) of HIV-1. The role of mode of delivery in the management of
- Empirical antibiotics targeting gram‐positive bacteria for the treatment of febrile neutropenic patients with cancer
Cochrane Systematic Reviews, 3-Jun-2017
The pattern of infections among neutropenic patients with cancer has shifted in the last decades to a predominance of gram-positive infections. Some of these gram-positive bacteria are increasingly resistant to beta-lactams and necessitate specific antibi
- Erythropoiesis‐stimulating agents for anaemia in chronic heart failure patients
Cochrane Systematic Reviews, 20-Jan-2010
Chronic heart failure (CHF) is a leading cause of morbidity and mortality worldwide. Anaemia is a common (12-55%) co-morbid condition and is associated with worsening symptoms and increased mortality. Anaemia is treatable and can be targeted in the treatm
- Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer
Cochrane Systematic Reviews, 8-Jul-2009
Tumour hypoxia increases tumour invasiveness and has a negative impact on response to therapy. Hypoxic tumours are also associated with severely anaemic individuals. It has therefore been hypothesised that correcting anaemia, by increasing haemoglobin lev
- Erythropoietin or darbepoetin for patients with cancer
Cochrane Systematic Reviews, 12-Dec-2012
Anaemia associated with cancer and cancer therapy is an important clinical factor in the treatment of malignant diseases. Therapeutic alternatives are recombinant human erythropoiesis stimulating agents (ESAs) and red blood cell transfusions.
- Family support for reducing morbidity and mortality in people with HIV/AIDS
Cochrane Systematic Reviews, 8-Jul-2009
Care and support play a critical role in assisting people who are HIV-positive to understand the need for prevention and to enable them to protect others. As the HIV/AIDS pandemic progresses and HIV-seropositive individuals contend with devastating illnes
- Fibrin sealant use for minimising peri‐operative allogeneic blood transfusion
Cochrane Systematic Reviews, 20-Jan-2003
Fibrin sealants (also referred to as biological glue or fibrin tissue adhesives) have gained increasing popularity as interventions to improve peri-operative (intra- and post-operative) haemostasis and diminish the need for allogeneic red cell transfusion
