Showing 581-600 of 746 for: Cochrane Systematic Reviews > Pharmacotherapeutics 
- Progestogen for treating threatened miscarriage
Cochrane Systematic Reviews, 6-Aug-2018
Miscarriage is a common complication encountered during pregnancy. It is defined as spontaneous pregnancy loss before 20 weeks' gestation. Progesterone's physiological role is to prepare the uterus for the implantation of the embryo, enhance uterine quies
- Progressive resistive exercise interventions for adults living with HIV/AIDS
Cochrane Systematic Reviews, 10-Nov-2008
Due to medical advancements, many people living with HIV infection in developed countries are living longer (Palella 1998). HIV infection can now present as a chronic illness with an uncertain natural disease history. The changing course of HIV infection
- Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer
Cochrane Systematic Reviews, 7-Oct-2021
This is an updated version of a Cochrane Review last published in 2013. Long-term central venous catheters (CVCs), including tunnelled CVCs (TCVCs) and totally implanted devices or ports (TIDs), are increasingly used when treating people with cancer. Desp
- Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical venous catheters
Cochrane Systematic Reviews, 15-Jan-2011
Umbilical venous catheters (UVCs) are often used in ill neonates. Infection related to the use of these catheters may cause significant morbidity and mortality. The use of prophylactic antibiotics has been advocated for newborns with umbilical venous cath
- Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia
Cochrane Systematic Reviews, 5-May-2016
Seizures are common following perinatal asphyxia and may exacerbate secondary neuronal injury. Barbiturate therapy has been used for infants with perinatal asphyxia in order to prevent seizures. However, barbiturate therapy may adversely affect neurodevel
- Prophylactic caffeine to prevent postoperative apnoea following general anaesthesia in preterm infants
Cochrane Systematic Reviews, 23-Oct-2001
Growing ex-preterm infants who undergo general anaesthesia for surgery at about term-equivalent age may have episodes of apnoea, cyanosis and bradycardia during the early postoperative period. A breathing stimulant such as caffeine given at the time of op
- Prophylactic doxapram for the prevention of morbidity and mortality in preterm infants undergoing endotracheal extubation
Cochrane Systematic Reviews, 24-Jul-2000
When preterm infants have been given intermittent positive pressure ventilation (IPPV) for respiratory failure, weaning from support and tracheal extubation may be difficult. A significant contributing factor is thought to be the relatively poor respirato
- Prophylactic methylxanthine for prevention of apnoea in preterm infants
Cochrane Systematic Reviews, 8-Dec-2010
Recurrent apnoea is common in preterm infants. These episodes can lead to hypoxaemia and bradycardia, which may be severe enough to require the use of positive pressure ventilation. In infants with apnoea, methylxanthine treatment has been used successful
- Prophylactic methylxanthines for endotracheal extubation in preterm infants
Cochrane Systematic Reviews, 25-Feb-2013
Weaning and extubating preterm infants on intermittent positive pressure ventilation (IPPV) for respiratory failure may be difficult. A significant contributing factor is thought to be the relatively poor respiratory drive and tendency to develop hypercar
- Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy
Cochrane Systematic Reviews, 8-Dec-2015
Twin pregnancies are associated with a high risk of neonatal mortality and morbidity due to an increased rate of preterm birth. Betamimetics can decrease contraction frequency or delay preterm birth in singleton pregnancies by 24 to 48 hours. The efficacy
- Prophylactic oral/topical non‐absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants
Cochrane Systematic Reviews, 24-Oct-2015
Invasive fungal infection is an important cause of mortality and morbidity in very preterm or very low birth weight infants. Uncertainty exists about the effect of prophylactic oral/topical non-absorbed antifungals to reduce mucocutaneous colonisation and
- Prophylactic steroids for pediatric open heart surgery
Cochrane Systematic Reviews, 12-May-2017
The immune response to cardiopulmonary bypass in infants and children can lead to a series of postoperative morbidities and mortality i.e. hemodynamic instability, increased infection and arrhythmias. The systemic Inflammatory response syndrome (SIRS) tha
- Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants
Cochrane Systematic Reviews, 24-Oct-2015
Invasive fungal infection is an important cause of mortality and morbidity in very preterm and very low birth weight infants. Early diagnosis is difficult and treatment is often delayed. Systemically absorbed antifungal agents (usually azoles) are increas
- Propranolol for migraine prophylaxis
Cochrane Systematic Reviews, 10-Jun-2019
Propranolol is one of the most commonly prescribed drugs for migraine prophylaxis.
- Proton pump inhibitor treatment for acute peptic ulcer bleeding
Cochrane Systematic Reviews, 13-Apr-2010
Randomised controlled trials (RCTs) evaluating the clinical effect of proton pump inhibitors (PPIs) in peptic ulcer (PU) bleeding yield conflicting results.
- Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding
Cochrane Systematic Reviews, 7-Jan-2022
Upper gastrointestinal (GI) bleeding is a common reason for emergency hospital admission. Proton pump inhibitors (PPIs) reduce gastric acid production and are used to manage upper GI bleeding. However, there is conflicting evidence regarding the clinical
- Psychosocial and pharmacological treatments versus pharmacological treatments for opioid detoxification
Cochrane Systematic Reviews, 7-Sep-2011
Different pharmacological approaches aimed at opioid detoxification are effective. Nevertheless a majority of patients relapse to heroin use, and relapses are a substantial problem in the rehabilitation of heroin users. Some studies have suggested that th
- Psychosocial combined with agonist maintenance treatments versus agonist maintenance treatments alone for treatment of opioid dependence
Cochrane Systematic Reviews, 5-Oct-2011
Maintenance treatments are effective in retaining patients in treatment and suppressing heroin use. Questions remain regarding the efficacy of additional psychosocial services.
- Psychosocial interventions for pregnant women in outpatient illicit drug treatment programs compared to other interventions
Cochrane Systematic Reviews, 3-Apr-2015
Illicit drug use in pregnancy is a complex social and public health problem. The consequences of drug use in pregnancy are high for both the woman and her child. Therefore, it is important to develop and evaluate effective treatments. There is evidence fo
- Psychosocial treatment for opiate abuse and dependence
Cochrane Systematic Reviews, 15-Apr-2014
Substance dependence is a social and public health problem; therefore it is a priority to develop effective treatments. Previous Cochrane reviews have explored the efficacy of pharmacotherapy for opiate dependence. This current review focuses on the role
