- Staples versus sutures for closing leg wounds after vein graft harvesting for coronary artery bypass surgery.
Cochrane Systematic Reviews, 24-Nov-2011
Surgical site infection (SSI) after saphenous vein graft harvesting is a complication occurring in up to 18% of patients who undergo coronary artery bypass surgery (CABG). It is not known whether the method of skin closure influences the infection rate. - Statin withdrawal in people with dementia
Cochrane Systematic Reviews, 9-Sep-2016
There are approximately 24 million people worldwide with dementia; this is likely to increase to 81 million by 2040. Dementia is a progressive condition, and usually leads to death eight to ten years after first symptoms. End-of-life care should emphasise - Statins and fibrates for preventing melanoma
Cochrane Systematic Reviews, 19-Oct-2005
Effective treatment for advanced melanoma is lacking. While no drug therapy currently exists for prevention of melanoma, in vitro, case-control, and animal model evidence suggest that lipid-lowering medications, commonly taken for high cholesterol, might - Statins for acute coronary syndrome
Cochrane Systematic Reviews, 1-Sep-2014
The early period following the onset of acute coronary syndrome (ACS) represents a critical stage of coronary heart disease, with a high risk of recurrent events and deaths. The short-term effects of early treatment with statins on patient-relevant outcom - Statins for acute ischemic stroke
Cochrane Systematic Reviews, 14-Jun-2011
Statins have been claimed to be effective in the acute phase of ischemic stroke. The potential positive actions of statins during an acute cerebrovascular ischemic event are two-fold: a neuroprotective effect, limiting damage and improving recovery; and a - Statins for age‐related macular degeneration
Cochrane Systematic Reviews, 4-Aug-2016
Age-related macular degeneration (AMD) is a progressive, late-onset disorder of the macula affecting central vision. It is the leading cause of blindness in people over 65 years in industrialized countries. Recent epidemiologic, genetic, and pathological - Statins for aortic valve stenosis
Cochrane Systematic Reviews, 5-Sep-2016
Aortic valve stenosis is the most common type of valvular heart disease in the USA and Europe. Aortic valve stenosis is considered similar to atherosclerotic disease. Some studies have evaluated statins for aortic valve stenosis. - Statins for asthma
Cochrane Systematic Reviews, 15-Jul-2020
Asthma is a common chronic respiratory disease. People with asthma have inflammation of their airways that causes recurrent episodes of wheezing, breathlessness and chest tightness, with or without a cough. Statins possess multiple therapeutic effects, in - Statins for children with familial hypercholesterolemia
Cochrane Systematic Reviews, 7-Nov-2019
Familial hypercholesterolemia is one of the most common inherited metabolic diseases and is an autosomal dominant disorder meaning heterozygotes, or carriers, are affected. Those who are homozygous have severe disease. The average worldwide prevalence of - Statins for multiple sclerosis
Cochrane Systematic Reviews, 7-Dec-2011
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system. Statins, prescribed as cholesterol lowering agents, have shown possible effects for treating MS in experimental and preliminary clinical studies. - Statins for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Cochrane Systematic Reviews, 23-Dec-2013
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common causes of elevated liver enzymes in the general population. NASH and to some extent NAFLD have been associated with increased liver-related and all-cause mortali - Statins for primary prevention of venous thromboembolism
Cochrane Systematic Reviews, 18-Dec-2014
Venous thromboembolism (VTE) is common in clinical practice. The efficacy of statins in the primary prevention of VTE remains unproven. This is an update of the review first published in 2011. - Statins for Smith‐Lemli‐Opitz syndrome
Cochrane Systematic Reviews, 14-Nov-2022
Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformations syndrome caused by defective cholesterol biosynthesis. Affected individuals show cholesterol deficiency and accumulation of various precursor molecules, mainly 7-dehydrocholesterol a - Statins for the prevention of dementia
Cochrane Systematic Reviews, 4-Jan-2016
This is an update of a Cochrane review first published in 2001 and then updated in 2009. Vascular risk factors including high cholesterol levels increase the risk of dementia due to Alzheimer's disease and of vascular dementia. Some observational studies - Statins for the primary prevention of cardiovascular disease
Cochrane Systematic Reviews, 31-Jan-2013
Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD) events in people with and without a past history of CVD is an important goal of pharmacotherapy. Statins are the first-choice agents. Previous reviews of the effects of statin - Statins for the treatment of dementia
Cochrane Systematic Reviews, 2-Jul-2014
The use of statin therapy in established Alzheimer's disease (AD) or vascular dementia (VaD) is a relatively unexplored area. In AD, ß-amyloid protein (Aß) is deposited in the form of extracellular plaques and previous studies have determined Aß generatio - Statins for women with polycystic ovary syndrome not actively trying to conceive
Cochrane Systematic Reviews, 7-Sep-2011
Statins, as lipid-lowering agents with pleiotropic actions, are likely not only to improve the dyslipidaemia associated with polycystic ovary syndrome but may also exert other beneficial metabolic and endocrine effects. - Statins versus placebo for people with chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 31-Jul-2019
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable respiratory disease. COPD exacerbations are associated with worse quality of life, increased hospitalisations, and increased mortality. Currently available pharmacologica - Stavudine or zidovudine in three-drug combination therapy for initial treatment of HIV infection in antiretroviral-naïve individuals
Cochrane Systematic Reviews, 15-Mar-2011
The introduction of highly active antiretroviral therapy (ART) as treatment for HIV infection has greatly improved mortality and morbidity for adults and children living with HIV around the world. Two common medications given in first-line antiretroviral - Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults.
Cochrane Systematic Reviews, 19-Apr-2006
A favourable regimen for people infected with HIV/AIDS is one that provides optimal efficacy, durability of antiretroviral activity, tolerability, and has low adverse effects and drug-drug interactions. The combination of the non-nucleoside reverse transc
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