- Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults
Cochrane Systematic Reviews, 27-Sep-2018
Dental pain can have a detrimental effect on quality of life. Symptomatic apical periodontitis and acute apical abscess are common causes of dental pain and arise from an inflamed or necrotic dental pulp, or infection of the pulpless root canal system. Cl - Systemic antibiotics for treating diabetic foot infections
Cochrane Systematic Reviews, 4-Sep-2015
Foot infection is the most common cause of non-traumatic amputation in people with diabetes. Most diabetic foot infections (DFIs) require systemic antibiotic therapy and the initial choice is usually empirical. Although there are many antibiotics availabl - Systemic antibiotics for treating malignant wounds
Cochrane Systematic Reviews, 24-Aug-2017
Malignant wounds are a devastating complication of cancer. They usually develop in the last six months of life, in the breast, chest wall or head and neck regions. They are very difficult to treat successfully, and the commonly associated symptoms of pain - Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations
Cochrane Systematic Reviews, 10-Nov-2008
Chronic suppurative otitis media (CSOM) causes ear discharge and impairs hearing. - Systemic antifungal therapy for tinea capitis in children
Cochrane Systematic Reviews, 12-May-2016
Tinea capitis is a common contagious fungal infection of the scalp in children. Systemic therapy is required for treatment and to prevent spread. This is an update of the original Cochrane review. - Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy
Cochrane Systematic Reviews, 13-Nov-2013
Percutaneous endoscopic gastrostomy (PEG) is a surgical procedure performed to maintain nutrition in the short- or long-term. During the procedure, a feeding tube that delivers either a liquid diet, or medication, via a clean or sterile delivery system, i - Systemic corticosteroid regimens for prevention of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 31-Jan-2017
Cochrane systematic reviews show that systemic postnatal corticosteroids reduce the risk of bronchopulmonary dysplasia (BPD) in preterm infants. However, corticosteroids have also been associated with an increased risk of neurodevelopmental impairment. It - Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease
Cochrane Systematic Reviews, 28-Aug-2014
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a major cause of hospital admission and mortality. They contribute to long-term decline in lung function, physical capacity and quality of life. The most common causes are infective, - Systemic corticosteroids for acute gout
Cochrane Systematic Reviews, 23-Apr-2008
Gout is one of the most frequently occurring rheumatic diseases, worldwide. Given the well-known drawbacks of the regular treatments for acute gout (non-steroidal anti-inflammatory drugs (NSAIDs), colchicine), systemic corticosteroids might be safe altern - Systemic corticosteroids for acute otitis media in children
Cochrane Systematic Reviews, 15-Mar-2018
Acute otitis media (AOM) is a common acute infection in children. Pain is its most prominent and distressing symptom. Antibiotics are commonly prescribed for AOM, although they have only a modest effect in reducing pain at two to three days. There is insu - Systemic corticosteroids for acute sinusitis
Cochrane Systematic Reviews, 25-Mar-2014
Acute sinusitis is the inflammation and swelling of the nasal and paranasal mucous membranes and is a common reason for patients to seek primary care consultations. The related impairment of daily functioning and quality of life is attributable to symptom - Systemic corticosteroids for radicular and non‐radicular low back pain
Cochrane Systematic Reviews, 21-Oct-2022
Corticosteroids are medications with anti-inflammatory and immunosuppressant properties. Systemic corticosteroids administered through the oral, intravenous, or intramuscular routes have been used to treat various types of low back pain, including radicul - Systemic corticosteroids for the management of cancer‐related breathlessness (dyspnoea) in adults
Cochrane Systematic Reviews, 20-Feb-2019
Dyspnoea is a common symptom in advanced cancer, with a prevalence of up to 70% among patients at end of life. The cause of dyspnoea is often multifactorial, and may cause considerable psychological distress and suffering. Dyspnoea is often undertreated a - Systemic corticosteroids for the treatment of COVID‐19: Equity‐related analyses and update on evidence
Cochrane Systematic Reviews, 17-Nov-2022
Systemic corticosteroids are used to treat people with COVID-19 because they counter hyper-inflammation. Existing evidence syntheses suggest a slight benefit on mortality. Nonetheless, size of effect, optimal therapy regimen, and selection of patients who - Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)
Cochrane Systematic Reviews, 13-Aug-2012
Recurrent aphthous stomatitis (RAS) is the most frequent form of oral ulceration, characterised by recurrent oral mucosal ulceration in an otherwise healthy individual. At its worst RAS can cause significant difficulties in eating and drinking. Treatment - Systemic interventions for severe atopic and vernal keratoconjunctivitis in children and young people up to the age of 16 years
Cochrane Systematic Reviews, 21-Oct-2020
Atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) are severe and potentially sight-threatening allergic eye diseases characterised by chronic inflammation of the ocular surface. Both topical and systemic treatments are used. This Coc - Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome
Cochrane Systematic Reviews, 11-Mar-2022
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare, severe cutaneous adverse reactions usually triggered by medications. In addition to tertiary-level supportive care, various systemic therapies have be - Systemic opioid regimens for postoperative pain in neonates
Cochrane Systematic Reviews, 16-Jan-2023
Postoperative pain clinical management in neonates has always been a challenging medical issue. Worldwide, several systemic opioid regimens are available for pediatricians, neonatologists, and general practitioners to control pain in neonates undergoing s - Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates
Cochrane Systematic Reviews, 3-Mar-2023
Neonates may undergo surgery because of malformations such as diaphragmatic hernia, gastroschisis, congenital heart disease, and hypertrophic pyloric stenosis, or complications of prematurity, such as necrotizing enterocolitis, spontaneous intestinal perf - Systemic pharmacological interventions for Ménière’s disease
Cochrane Systematic Reviews, 23-Feb-2023
Ménière's disease is a condition that causes recurrent episodes of vertigo, associated with hearing loss and tinnitus. A number of pharmacological interventions have been used in the management of this condition, including betahistine, diuretics, antivira
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