Showing 61-80 of 197 for: Cochrane Systematic Reviews > Hematologic 
- Fibrin sealant use for minimising peri-operative allogeneic blood transfusion
Cochrane Systematic Reviews, 12-May-2009
Fibrin sealants (also referred to as biological glue or fibrin tissue adhesives) have gained increasing popularity as interventions to improve peri-operative (intra- and post-operative) haemostasis and diminish the need for allogeneic red cell transfusion
- Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
Cochrane Systematic Reviews, 4-Mar-2015
Treating vaso-occlusive painful crises in people with sickle cell disease is complex and requires multiple interventions. Extra fluids are routinely given as adjunct treatment, regardless of the individual's state of hydration with the aim of slowing or s
- Folate for depressive disorders
Cochrane Systematic Reviews, 31-Oct-2008
There are a number of effective interventions for the treatment of depression. It is possible that the efficacy of these treatments will be improved further by the use of adjunctive therapies such as folate.
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
Cochrane Systematic Reviews, 15-Jul-2014
Methotrexate (MTX) is a disease modifying antirheumatic drug (DMARD) used as a first line agent for treating rheumatoid arthritis (RA). Pharmacologically, it is classified as an antimetabolite due to its antagonistic effect on folic acid metabolism. Many
- Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people
Cochrane Systematic Reviews, 30-Nov-2008
Folate deficiency can result in congenital neural tube defects and megaloblastic anaemia. Low folate levels may be due to insufficient dietary intake or inefficient absorption, but impaired metabolic utilization also occurs.
- Frequency of administration of erythropoiesis-stimulating agents for the anaemia of end-stage kidney disease in dialysis patients
Cochrane Systematic Reviews, 12-Nov-2014
The benefits of erythropoiesis-stimulating agents (ESA) for dialysis patients have been demonstrated. However, it remains unclear whether the efficacy and safety of new, longer-acting ESA given less frequently is equivalent to recombinant human erythropoi
- Gene therapy for sickle cell disease
Cochrane Systematic Reviews, 1-Oct-2014
Sickle cell disease encompasses a group of genetic disorders characterized by the presence of at least one hemoglobin S (Hb S) allele, and a second abnormal allele that could allow abnormal hemoglobin polymerisation leading to a symptomatic disorder.
- Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia
Cochrane Systematic Reviews, 28-Aug-2011
Neonates have immature granulopoiesis, which frequently results in neutropenia after sepsis. Neutropaenic septic neonates have a higher mortality than non-neutropenic septic neonates. Therefore, granulocyte transfusion to septic neutropenic neonates may i
- Granulocyte transfusions for treating infections in patients with neutropenia or neutrophil dysfunction
Cochrane Systematic Reviews, 5-Jul-2010
Transfusions of granulocytes have a long history of usage in clinical practice to support and treat severe infection in high risk groups of patients with neutropenia or neutrophil dysfunction. However, there is considerable current variability in therapeu
- Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum
Cochrane Systematic Reviews, 16-May-2012
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterised by systemic intravascular activation of coagulation. There are several obstetric causes of DIC during pregnancy and postpartum.
- Haemoglobin and haematocrit targets for the anaemia of chronic kidney disease
Cochrane Systematic Reviews, 13-Jan-2010
Anaemia affects 60% to 80% of patients with chronic kidney disease (CKD) reduces quality of life and is a risk factor for early death. Treatment options are blood transfusion, erythropoietin (EPO) and darbepoetin alfa. Recently higher haemoglobin (Hb) and
- Hematopoietic stem cell transplantation for people with ß-thalassaemia major
Cochrane Systematic Reviews, 13-Apr-2015
Thalassemia is an inherited blood disorder, caused by mutations in regulatory genes and transmitted as an autosomal recessive disorder, which results in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia ma
- Heparin for pregnant women with acquired or inherited thrombophilias
Cochrane Systematic Reviews, 8-Aug-2012
Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin a
- Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction)
Cochrane Systematic Reviews, 7-May-2014
Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ
- Herbal medicines for treating HIV infection and AIDS
Cochrane Systematic Reviews, 10-Nov-2008
HIV-infected people and AIDS patients often seek complementary therapies including herbal medicines due to reasons such as unsatisfactory effects, high cost, non-availability, or adverse effects of conventional medicines.
- Home-based HIV voluntary counselling and testing (VCT) for improving uptake of HIV testing
Cochrane Systematic Reviews, 15-Jun-2010
The low uptake of HIV voluntary counselling and testing (VCT) has hindered global attempts to prevent new HIV infections and has limited scale-up of HIV care and treatment. Globally, only 10% of HIV-infected individuals are aware of their HIV status. One
- Hormone replacement for osteoporosis in women with primary biliary cirrhosis
Cochrane Systematic Reviews, 12-Nov-2011
Women with primary biliary cirrhosis often suffer from postmenopausal osteoporosis due to their age, or osteoporosis secondary to their liver disease, or treatments provided for their liver disease. Hormone replacement increases bone mineral density and r
- Hydrocolloid dressings for healing diabetic foot ulcers
Cochrane Systematic Reviews, 6-Aug-2013
Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including hydrocolloid dr
- Hydroxyurea (hydroxycarbamide) for sickle cell disease
Cochrane Systematic Reviews, 1-Sep-2022
Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical probl
- Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates
Cochrane Systematic Reviews, 11-Nov-2008
Exchange transfusion and phototherapy have traditionally been used to treat jaundice and avoid the associated neurological complications. Exchange transfusion is not without risk and intravenous immunoglobulin has been suggested as an alternative therapy
