Showing 61-80 of 197 for: Cochrane Systematic Reviews > Hematologic 
- Fluid replacement therapy for acute episodes of pain in people with sickle cell disease
Cochrane Systematic Reviews, 31-Jul-2017
Treating vaso-occlusive painful crises in people with sickle cell disease is complex and requires multiple interventions. Extra fluids are routinely given as adjunct treatment, regardless of the individual's state of hydration with the aim of slowing or s
- Folate for depressive disorders
Cochrane Systematic Reviews, 22-Apr-2003
There are a number of effective interventions for the treatment of depression. It is possible that the efficacy of these treatments will be improved further by the use of adjunctive therapies such as folate.
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis
Cochrane Systematic Reviews, 31-May-2013
Methotrexate (MTX) is a disease modifying antirheumatic drug (DMARD) used as a first line agent for treating rheumatoid arthritis (RA). Pharmacologically, it is classified as an antimetabolite due to its antagonistic effect on folic acid metabolism. Many
- Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people
Cochrane Systematic Reviews, 8-Oct-2008
Folate deficiency can result in congenital neural tube defects and megaloblastic anaemia. Low folate levels may be due to insufficient dietary intake or inefficient absorption, but impaired metabolic utilization also occurs.
- Frequency of administration of erythropoiesis‐stimulating agents for the anaemia of end‐stage kidney disease in dialysis patients
Cochrane Systematic Reviews, 28-May-2014
The benefits of erythropoiesis-stimulating agents (ESA) for dialysis patients have been demonstrated. However, it remains unclear whether the efficacy and safety of new, longer-acting ESA given less frequently is equivalent to recombinant human erythropoi
- Gene therapy for sickle cell disease
Cochrane Systematic Reviews, 30-Nov-2020
Sickle cell disease encompasses a group of genetic disorders characterized by the presence of at least one hemoglobin S (Hb S) allele, and a second abnormal allele that could allow abnormal haemoglobin polymerisation leading to a symptomatic disorder.
- Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropenia
Cochrane Systematic Reviews, 5-Oct-2011
Neonates have immature granulopoiesis, which frequently results in neutropenia after sepsis. Neutropaenic septic neonates have a higher mortality than non-neutropenic septic neonates. Therefore, granulocyte transfusion to septic neutropenic neonates may i
- Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction
Cochrane Systematic Reviews, 29-Apr-2016
Despite modern antimicrobials and supportive therapy bacterial and fungal infections are still major complications in people with prolonged disease-related or treatment-related neutropenia. Transfusions of granulocytes have a long history of usage in clin
- Haematological interventions for treating disseminated intravascular coagulation during pregnancy and postpartum
Cochrane Systematic Reviews, 16-May-2012
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterised by systemic intravascular activation of coagulation. There are several obstetric causes of DIC during pregnancy and postpartum.
- Haemoglobin and haematocrit targets for the anaemia of chronic kidney disease
Cochrane Systematic Reviews, 13-Jan-2010
Anaemia affects 60% to 80% of patients with chronic kidney disease (CKD) reduces quality of life and is a risk factor for early death. Treatment options are blood transfusion, erythropoietin (EPO) and darbepoetin alfa. Recently higher haemoglobin (Hb) and
- Hematopoietic stem cell transplantation for people with β‐thalassaemia
Cochrane Systematic Reviews, 21-Apr-2021
Thalassaemia is an autosomal recessive blood disorder, caused by mutations in globin genes or their regulatory regions, resulting in a reduced rate of synthesis of one of the globin chains that make up haemoglobin. In ß-thalassaemia there is an underprodu
- Heparin for pregnant women with acquired or inherited thrombophilias
Cochrane Systematic Reviews, 22-Apr-2003
Thrombophilias, which are associated with a predisposition to thrombotic events, have been implicated in adverse obstetrical outcomes such as intrauterine growth restriction, stillbirth, severe early onset pre-eclampsia, and placental abruption. Heparin a
- Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction)
Cochrane Systematic Reviews, 7-May-2014
Venous thromboembolic disease has been extensively studied in surgical patients. The benefit of thromboprophylaxis is now generally accepted, but it is medical patients who make up the greater proportion of the hospital population. Medical patients differ
- Herbal medicines for treating HIV infection and AIDS
Cochrane Systematic Reviews, 20-Jul-2005
HIV-infected people and AIDS patients often seek complementary therapies including herbal medicines due to reasons such as unsatisfactory effects, high cost, non-availability, or adverse effects of conventional medicines.
- Home‐based HIV voluntary counselling and testing (VCT) for improving uptake of HIV testing
Cochrane Systematic Reviews, 7-Jul-2010
The low uptake of HIV voluntary counselling and testing (VCT) has hindered global attempts to prevent new HIV infections and has limited scale-up of HIV care and treatment. Globally, only 10% of HIV-infected individuals are aware of their HIV status. One
- Hormone replacement for osteoporosis in women with primary biliary cirrhosis
Cochrane Systematic Reviews, 12-Nov-2011
Women with primary biliary cirrhosis often suffer from postmenopausal osteoporosis due to their age, or osteoporosis secondary to their liver disease, or treatments provided for their liver disease. Hormone replacement increases bone mineral density and r
- Hydrocolloid dressings for healing diabetic foot ulcers
Cochrane Systematic Reviews, 6-Aug-2013
Foot ulcers in people with diabetes are a prevalent and serious global health issue. Wound dressings are regarded as important components of ulcer treatment, with clinicians and patients having many different types to choose from including hydrocolloid dr
- Hydroxyurea (hydroxycarbamide) for sickle cell disease
Cochrane Systematic Reviews, 20-Apr-2017
Sickle cell disease (SCD) is one of the most common inherited diseases worldwide. It is associated with lifelong morbidity and a reduced life expectancy. Hydroxyurea (hydroxycarbamide), an oral chemotherapeutic drug, ameliorates some of the clinical probl
- Immunoglobulin for alloimmune hemolytic disease in neonates
Cochrane Systematic Reviews, 18-Mar-2018
Exchange transfusion and phototherapy have traditionally been used to treat jaundice and avoid the associated neurological complications. Because of the risks and burdens of exchange transfusion, intravenous immunoglobulin (IVIg) has been suggested as an
- Immunoglobulin for multifocal motor neuropathy
Cochrane Systematic Reviews, 11-Jan-2022
Multifocal motor neuropathy (MMN) is a rare, probably immune-mediated disorder characterised by slowly progressive, asymmetric, distal weakness of one or more limbs with no objective loss of sensation. It may cause prolonged periods of disability. Treatme
