- Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19
Cochrane Systematic Reviews, 12-Feb-2021
The coronavirus disease 2019 (COVID-19) pandemic has resulted in substantial mortality. Some specialists proposed chloroquine (CQ) and hydroxychloroquine (HCQ) for treating or preventing the disease. The efficacy and safety of these drugs have been assess - Chlorproguanil‐dapsone for treating uncomplicated malaria
Cochrane Systematic Reviews, 18-Oct-2004
Using a pilot system we have categorised this review as: Historical question - no update intended. (Please see "Published notes" section of the review for more details). - Chlorpromazine dose for people with schizophrenia
Cochrane Systematic Reviews, 13-Apr-2017
The World Health Organization (WHO) Model Lists of Essential Medicines lists chlorpromazine as one of its five medicines used in psychotic disorders. - Chlorpromazine for psychosis induced aggression or agitation
Cochrane Systematic Reviews, 9-Nov-2010
Agitated or violent behaviour constitutes 10% of all emergency psychiatric treatment. Some guidelines do not recommend the use of chlorpromazine for rapid tranquillisation but it is still often used for this purpose. - Chlorpromazine versus atypical antipsychotic drugs for schizophrenia
Cochrane Systematic Reviews, 5-Apr-2016
Chlorpromazine is an aliphatic phenothiazine, which is one of the widely-used typical antipsychotic drugs. Chlorpromazine is reliable for its efficacy and one of the most tested first generation antipsychotic drugs. It has been used as a ‘gold standard’ t - Chlorpromazine versus clotiapine for schizophrenia
Cochrane Systematic Reviews, 7-Apr-2017
Schizophrenia is a chronic, disabling and severe mental disorder, characterised by disturbance in perception, thought, language, affect and motor behaviour. Chlorpromazine and clotiapine are among antipsychotic drugs used for the treatment of people with - Chlorpromazine versus metiapine for schizophrenia
Cochrane Systematic Reviews, 25-Mar-2017
Chlorpromazine, a widely available and inexpensive antipsychotic drug, is considered the benchmark treatment for schizophrenia worldwide. Metiapine, a dibenzothiazepine derivative, has been reported to have potent antipsychotic characteristics. However, n - Chlorpromazine versus penfluridol for schizophrenia
Cochrane Systematic Reviews, 23-Sep-2017
The efficacy of chlorpromazine, a benchmark antipsychotic, has not been fully assessed in direct comparison with different individual antipsychotics. Penfluridol is another old antipsychotic with a long half-life so one oral dose may last up to one week. - Chlorpromazine versus piperacetazine for schizophrenia
Cochrane Systematic Reviews, 31-Oct-2018
Schizophrenia is a severe mental disorder with a prevalence of about 1% among the general population. It is listed among the top 10 causes of disability-adjusted life years (DALYs) worldwide. Antipsychotics are the mainstay treatment. Piperacetazine has b - Chlorpromazine versus placebo for schizophrenia
Cochrane Systematic Reviews, 2-Nov-2015
Chlorpromazine, formulated in the 1950s, remains a benchmark treatment for people with schizophrenia. - Chlorpromazine versus reserpine for schizophrenia
Cochrane Systematic Reviews, 28-Apr-2016
In the 1940s reserpine, refined from a plant extract that had been used for centuries, began to be used as a treatment for people with mental disorders and was one of the very first antipsychotic drugs. Its irreversible pharmacological potency and adverse - Cholecystectomy deferral in patients with endoscopic sphincterotomy
Cochrane Systematic Reviews, 17-Oct-2007
Cholecystectomy is not required in up to 64% of patients who adopt a wait-and-see policy after endoscopic clearance of common bile duct stones. Although reports of retrospective cohort series have shown a higher mortality among patients who defer cholecys - Cholecystectomy for gallbladder polyp
Cochrane Systematic Reviews, 21-Jan-2009
The management of gallbladder polyps is controversial. Cholecystectomy has been recommended for gallbladder polyps larger than 10 mm because of the association with gallbladder cancer. Cholecystectomy has also been suggested for gallbladder polyps smaller - Cholecystectomy for patients with silent gallstones
Cochrane Systematic Reviews, 24-Jan-2007
Cholecystectomy is currently advised only for patients with symptomatic gallstones. However, about 4% of patients with asymptomatic gallstones develop symptoms including cholecystitis, obstructive jaundice, pancreatitis, and gallbladder cancer. - Cholecystectomy for suspected gallbladder dyskinesia
Cochrane Systematic Reviews, 21-Jan-2009
The optimal treatment for patients with suspected biliary dyskinesia is controversial. Some studies found that cholecystectomy produced symptomatic improvement in patients with gallbladder dyskinesia (diagnosed by low gallbladder ejection fraction) while - Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage
Cochrane Systematic Reviews, 8-Mar-2013
Cerebral vasospasm and related delayed ischaemic deficits (DIDs) occur in about 17% to 40% of patients with aneurysmal subarachnoid haemorrhage (SAH) and lead to a poor outcome. Cholesterol-reducing agents might improve unfavourable outcomes. - Cholinergic medication for antipsychotic‐induced tardive dyskinesia
Cochrane Systematic Reviews, 19-Mar-2018
Tardive dyskinesia (TD) remains a troublesome adverse effect of conventional antipsychotic (neuroleptic) medication. It has been proposed that TD could have a component of central cholinergic deficiency. Cholinergic drugs have been used to treat TD. - Cholinesterase inhibitors for Alzheimer's disease
Cochrane Systematic Reviews, 18-Mar-2016
** This review is awaiting update with a new protocol. The methods used for the review were acceptable when the review was published but do not meet contemporary standards, and the review is also considerably out of date. Therefore, readers should note th - Cholinesterase inhibitors for delirium
Cochrane Systematic Reviews, 23-Jan-2008
Delirium is now the preferred term to describe acute confusional states. It is experienced by 10 to 30% of all hospital inpatients. Delirium is potentially reversible and is related to several adverse outcomes, including increased hospital length of stay, - Cholinesterase inhibitors for dementia with Lewy bodies
Cochrane Systematic Reviews, 27-Apr-2008
Dementia with Lewy bodies (DLB) was first described in 1983, and clinical diagnostic criteria were published in the early to mid 1990s. It has been suggested DLB may account for up to 15-25% of cases of dementia among people aged over 65, although autopsy
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