Showing 141-160 of 498 for: Cochrane Systematic Reviews > Neurologic 
- Donepezil for mild cognitive impairment
Cochrane Systematic Reviews, 19-Jul-2006
Problems with memory which do not meet the diagnostic criteria for dementia, usually called mild cognitive impairment (MCI), can be the first sign of an impending dementia, particularly Alzheimer's disease (AD). There is no consensus on a definition or di
- Donepezil for vascular cognitive impairment
Cochrane Systematic Reviews, 26-Jan-2004
Vascular disease is the second commonest cause of dementia after Alzheimer's disease. There are difficulties in classifying patients with this type of cognitive impairment owing to varied clinical presentation and different types of arterial disease. Ther
- Dopamine agonist therapy in early Parkinson's disease
Cochrane Systematic Reviews, 12-Nov-2008
Dopamine agonists are being used increasingly as first line treatment for Parkinson's disease, but there remains uncertainty about their clinical and cost-effectiveness relative to levodopa.
- Dopamine agonists for the treatment of restless legs syndrome
Cochrane Systematic Reviews, 24-Mar-2011
According to clinical guidelines, dopamine agonists are the first-line treatment of restless legs syndrome (RLS).
- Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children
Cochrane Systematic Reviews, 10-Jan-2018
Tonic-clonic convulsions and convulsive status epilepticus (currently defined as a tonic-clonic convulsion lasting at least 30 minutes) are medical emergencies and require urgent and appropriate anticonvulsant treatment. International consensus is that an
- Drug therapy for chronic idiopathic axonal polyneuropathy
Cochrane Systematic Reviews, 20-Jun-2017
Chronic idiopathic axonal polyneuropathy (CIAP) is an insidiously progressive sensory or sensorimotor polyneuropathy that affects elderly people. Although severe disability or handicap does not occur, CIAP reduces quality of life. CIAP is diagnosed in 10%
- Drug therapy for delirium in terminally ill adults
Cochrane Systematic Reviews, 21-Jan-2020
Delirium is a syndrome characterised by an acute disturbance of attention and awareness which develops over a short time period and fluctuates in severity over the course of the day. It is commonly experienced during inpatient admission in the terminal ph
- Drug therapy for obstructive sleep apnoea in adults
Cochrane Systematic Reviews, 30-Apr-2013
The treatment of choice for moderate to severe obstructive sleep apnoea (OSA) is continuous positive airways pressure (CPAP) applied via a mask during sleep. However, this is not tolerated by all individuals and its role in mild OSA is not proven. Drug th
- Drug therapy for the management of cancer-related fatigue
Cochrane Systematic Reviews, 1-Aug-2010
This review is an update of a previously published review in The Cochrane Database of Systematic Reviews (Issue 1 2008). Cancer-related fatigue (CRF) is common, under-recognised and difficult to treat. There have been studies looking at drug interventions
- Drug treatment for facioscapulohumeral muscular dystrophy
Cochrane Systematic Reviews, 19-Apr-2004
Facioscapulohumeral muscular dystrophy is a progressive muscle disease which has no agreed treatment. Early suggestions that corticosteroids might be helpful were not supported by a subsequent open label study. The beta 2 adrenergic agonist albuterol, als
- Drug treatment for myotonia
Cochrane Systematic Reviews, 10-May-2011
Abnormal delayed relaxation of skeletal muscles, known as myotonia, can cause disability in myotonic disorders. Sodium channel blockers, tricyclic antidepressive drugs, benzodiazepines, calcium-antagonists, taurine and prednisone may be of use in reducing
- Drug treatment for spinal muscular atrophy type I
Cochrane Systematic Reviews, 11-Dec-2019
Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in combination with a point mutation in the second SMN1 allele. This results in degeneration of anterio
- Drug treatment for spinal muscular atrophy types II and III
Cochrane Systematic Reviews, 6-Jan-2020
Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in combination with a (point) mutation in the second SMN1 allele. This results in degeneration of anter
- Drugs for preventing migraine headaches in children
Cochrane Systematic Reviews, 10-Jun-2019
It has been estimated that about 10 per cent of children between 6 and 20 years of age suffer from migraine, and that children with migraine lose one and a half weeks more schooling per year than their peers. Prophylactic drugs can be prescribed when chil
- Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants
Cochrane Systematic Reviews, 21-Oct-2021
Bronchopulmonary dysplasia (BPD) remains a major problem for infants born extremely preterm. Persistent inflammation in the lungs is important in its pathogenesis. Systemic corticosteroids have been used to prevent or treat BPD because of their potent ant
- Early versus late antiepileptic drug withdrawal for people with epilepsy in remission
Cochrane Systematic Reviews, 12-Feb-2015
Epilepsy is a chronic neurological disorder which affects millions of people around the world. Antiepileptic drugs (AED) are the main interventions used to prevent seizures and control epilepsy. Although effective in most cases, AEDs are related to long-t
- Early volume expansion for prevention of morbidity and mortality in very preterm infants
Cochrane Systematic Reviews, 19-Apr-2004
Reduced perfusion of organs such as the brain, heart, kidneys and the gastrointestinal tract may lead to acute dysfunction and be associated with permanent injury. Various strategies have been used to provide cardiovascular support to preterm infants incl
- Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia
Cochrane Systematic Reviews, 15-Jun-2017
Prevention of cognitive impairment and dementia is an important public health goal. Epidemiological evidence shows a relationship between cognitive impairment and Type 2 diabetes mellitus. The risk of dementia increases with duration of disease. This upda
- Electrical stimulation for preventing and treating post‐stroke shoulder pain
Cochrane Systematic Reviews, 23-Oct-2000
Shoulder pain after stroke is common and disabling. The optimal management is uncertain, but electrical stimulation (ES) is often used to treat and prevent pain.
- Electroconvulsive therapy for the depressed elderly
Cochrane Systematic Reviews, 22-Apr-2003
Depressive disorders are common in old age, with serious health consequences such as increased morbidity, disability, and mortality. The frailty of elderly people may seriously hamper the efficacy and safety of pharmacotherapy. Therefore, electroconvulsiv
