- Rhabdomyosarcoma
Essential Evidence Topics, 30-Dec-2021
Overall Bottom Line: Rhabdomysocarcoma is detected clinically and is confirmed via biopsy. Initial imaging is radiographic, followed by CT without contrast or MRI. Prognosis is based on histologic characteristics and extent of disease. Initial treat - Skin cancer (basal cell)
Essential Evidence Topics, 16-Feb-2021
Overall Bottom Line: Look for clinical features that are suspicious for all subtypes of basal cell carcinoma (BCC) including nodular (pearly with telangiectasias), superficial (scaling and thready border), and sclerosing (scarlike). Biopsy suspicious le - Skin cancer (melanoma)
Essential Evidence Topics, 23-Dec-2021
Overall Bottom Line: Examine closely any lesion that a patient states is changing in size, shape, symptoms (itching, tenderness), surface (especially bleeding), and shades of color. Look for the ABCDE criteria (). Dermoscopy is more sensitive than the u - Skin cancer (squamous cell carcinoma)
Essential Evidence Topics, 5-Jul-2021
Overall Bottom Line: Biopsy any growing or ulcerated lesion that does not heal, bleeds easily, or steadily grows in a sun-exposed area or a mucus membrane. Surgical resection for definitive treatment of squamous cell carcinoma (SCC) should include margi - Stomach cancer
Essential Evidence Topics, 19-Nov-2021
Overall Bottom Line: Presenting symptoms are mostly commonly loss of appetite, weight loss, and abdominal pain of recent onset. Upper endoscopy is the recommended initial diagnostic test. For carcinoma of the stomach, surgery is the primary therapy, but - Testicular cancer
Essential Evidence Topics, 14-Oct-2021
Overall Bottom Line: Men presenting with a solid, firm testicular mass are presumed to have testicular cancer until proven otherwise. Ultrasound is the best initial diagnostic test. Histologic evaluation is required for all men with confirmed testicular - Thyroid cancer
Essential Evidence Topics, 19-Nov-2021
Overall Bottom Line: A history and physical examination aimed at identifying any potential risk for malignancy should be performed in all patients with thyroid nodules. Conduct fine needle aspiration of thyroid nodules to rule out malignancy based on ul - Thyroid nodule
Essential Evidence Topics, 23-Mar-2022
Overall Bottom Line: Obtain a thyroid-stimulating hormone (TSH) test and high-resolution ultrasound (HRUS) in the initial evaluation of a thyroid nodule. Ultrasound for thyroid nodule evaluation identifies nodules at risk of being malignant. The ACR TI- - Uterine cancer
Essential Evidence Topics, 22-Mar-2021
Overall Bottom Line: All women with postmenopausal bleeding or older than 35 years with abnormal uterine bleeding should be evaluated for endometrial cancer. Either endometrial biopsy or transvaginal ultrasound (TVUS) is appropriate diagnostic option. - Vaginal and vulvar malignancy
Essential Evidence Topics, 22-Mar-2021
Overall Bottom Line: Vaginal and vulvar malignancies are quite rare, so screening asymptomatic women is not cost effective. The earliest possible diagnosis requires the clinician to proceed quickly to biopsy of suspicious lesions. Vulvar intraepitheli - Zollinger-Ellison syndrome
Essential Evidence Topics, 12-Apr-2021
Overall Bottom Line: Consider Zollinger-Ellison syndrome (ZES) in patients with peptic ulcer disease refractory to proton pump inhibitors (PPIs), ulcers distal to the duodenal bulb, multiple peptic ulcers, or family history of multiple endocrine neoplasia
Essential Evidence is a powerful, one-stop, state-of-the-art reference that includes best-evidence answers to your most important clinical questions concerning symptoms, diseases, and treatment. Its concise, highly structured content is tightly integrated and hyperlinked to thousands of calculators, articles, and evidence summaries within Essential Evidence Plus to make searching for answers quick and seamless. Each topic has a “strength of evidence” rating for every recommendation, a “Bottom-line” summary that introduces each section, and a broad array of helpful algorithms.
